Qualitative and Quantitative Analyses of Brain 18Fluoro-Deoxy-Glucose Positron Emission Tomography in Primary Progressive Aphasia.

CONCLUSIONS: Brain 18F-FDG PET had an elevated performance in the early diagnosis of PPA variants and in the advanced PPA AD/FTD classification. QL clarified the development of AD or FTD in advanced PPA cases and supported the differential diagnosis of a PPA variant in a few early cases. QN 18F-FDG PET evaluation better contributed to the early diagnosis of an unclear metabolic pattern. To correctly identify all cases, patients with diffuse cortical hypometabolism were also included. Larger series are necessary to confirm these data. PMID: 32062656 [PubMed - as supplied by publisher]
Source: Dementia and Geriatric Cognitive Disorders - Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

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Can you distinguish the taste of a red wine versus a rosé? How about the look of a 1960s muscle car versus a foreign import? Do you prefer to grow lilies or tulips? Would you rather listen to Dark Side of the Moon or “Fly Me to the Moon”? To answer any of these questions, you need to use your semantic memory. Your semantic memory is your store of factual knowledge of the world and the meaning of words. It’s how you know that a fork is for eating (not twirling your hair) and what color a lion is. It’s both the source of your vocabulary and how you know what something does even if you don&rsquo...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Alzheimer's Disease Brain and cognitive health Healthy Aging Memory Source Type: blogs
Conclusions: This study improves the knowledge on clinical significance of RBD symptoms in ET patients. Our preliminary findings demonstrate that presence of RBD in ET is associated with neurocognitive impairment, but not with cardiac autonomic dysfunction. Further longitudinal studies are needed to investigate whether ET patients with RBD will develop a frank dementia over the time. Introduction Essential tremor (ET) is one of the most common neurological disease among adults. Traditionally, it is defined by a core of clinical motor symptoms characterized by kinetic/postural tremor affecting hand, head, or other par...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Wei Li1†, Wei-Min Xiao1†, Yang-Kun Chen1*, Jian-Feng Qu1, Yong-Lin Liu1, Xue-Wen Fang2, Han-Yu Weng1 and Gen-Pei Luo11Department of Neurology, Dongguan People’s Hospital, Dongguan, China2Department of Radiology, Dongguan People’s Hospital, Dongguan, ChinaBackground: Anxiety is prevalent after a stroke. The pathophysiological mechanisms underlying the development of poststroke anxiety (PSA) remain unclear. The aim of this study was to investigate the clinical and neuroimaging risk factors for development of PSA and examine the effects of PSA on activities of daily living (ADL) and quality of life (...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Vincenzo Tigano1, Giuseppe Lucio Cascini2, Cristina Sanchez-Castañeda3, Patrice Péran4 and Umberto Sabatini5* 1Department of Juridical, Historical, Economic and Social Sciences, University of Magna Graecia, Catanzaro, Italy 2Department of Experimental and Clinical Medicine, University of Magna Graecia, Catanzaro, Italy 3Department of Clinical Psychology and Psychobiology, University of Barcelona, Barcelona, Spain 4ToNIC, Toulouse NeuroImaging Center, Université de Toulouse, Inserm, UPS, Toulouse, France 5Department of Medical and Surgical Sciences, University of Magna Graecia, Catanzaro, Ita...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
ConclusionsIn the present study, our automated classifier successfully classified FTD clinical subtypes with good to excellent accuracy. Our classifier may help clinicians diagnose FTD subtypes with subtle cortical atrophy and facilitate appropriate specific interventions.
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Semin Neurol 2019; 39: 213-226 DOI: 10.1055/s-0039-1681041Alzheimer's disease (AD) is the commonest neurodegenerative disease and the most frequent cause of dementia. It affects 30 million people worldwide. Current research criteria focus on biomarkers' status for amyloid and tau using positron emission tomography and cerebrospinal fluid analysis, independent of clinical status. Current epidemiological data, which mostly rely on biomarker-undetermined AD cases, have highlighted ApoE4 and age as the main risk factors. Rare autosomal dominant mutations also account for a small fraction of early-onset AD. The main clinical ph...
Source: Seminars in Neurology - Category: Neurology Authors: Tags: Review Article Source Type: research
We examined associations between 18F‐flortaucipir and cognition in 14 mildly‐impaired patients (12 with cerebrospinal fluid analytes consistent with AD pathology) who had amnestic (n = 5) and non‐amnestic AD syndromes, including posterior cortical atrophy (PCA, n = 5) and logopenic‐variant primary progressive aphasia (lvPPA, n = 4). Amnestic AD patients had deficits in memory; lvPPA in language; and both amnestic AD and PCA patients in visuospatial function. Associations with cognition were tested using sparse regression and compared to associations in anatomical regions‐...
Source: Human Brain Mapping - Category: Neurology Authors: Tags: RESEARCH ARTICLE Source Type: research
AbstractNeuropathological andin vivo studies have revealed a tight relationship between tau pathology and cognitive impairment across the Alzheimer ’s disease spectrum. However, tau pathology is also intimately associated with neurodegeneration and amyloid pathology. The aim of the present study was therefore to assess whether grey matter atrophy and amyloid pathology contribute to the relationship between tau pathology, as measured with18F-AV-1451-PET imaging, and cognitive deficits in Alzheimer ’s disease. We included 40 amyloid-positive patients meeting criteria for mild cognitive impairment due to Alzheimer...
Source: Brain - Category: Neurology Source Type: research
627Objectives: Animal studies and the brain atrophy pattern in patients with tau-related neurodegenerative dementias suggest that tau protein aggregates may propagate in a manner similar to infectious prions, spreading through brain networks. However, tau propagation in this manner has not been demonstrated in vivo in humans. This may now become feasible, given the availability of tau PET imaging agents. Alzheimer’s disease affects the complex resting network and therefore is not a good model to study tau propagation. By contrast, the non-fluent variant of primary progressive aphasia (nfvPPA) is a neurodegenerative d...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Novel Clinical Applications in Tauopathy and Epilepsy Source Type: research
Conclusion: Although both CSF-markers of p-tau and t-tau do not distinguish between AD types, global in vivo tau deposition and p-tau showed a selective association in typical but not atypical AD. Although preliminary, this result suggests that CSF tau marker in atypical AD do not reflect the extent of the pathological tau burden. We additionally identified a distinct spatial signature of each marker to in vivo regional tau burden in typical and atypical AD which may relate to the generally different distribution of tau deposits in different disease entities. We conclude that in vivo tau imaging can differentiate typical f...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Novel Clinical Applications in Tauopathy and Epilepsy Source Type: research
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