Anti-leukemic effect of PI3K inhibition on chronic myeloid leukemia (CML) cells: shedding new light on the mitigating effect of c-Myc and autophagy on BKM120 cytotoxicity.

In conclusion, the results of the present study showed that the abrogation of PI3K using BKM120 might be a befitting approach in CML treatment, either as a single agent or in a combined-modal strategy; however, further evaluations including clinical trials and in vivo investigations are demanded to ascertain the safety and the efficacy of the inhibitor in treatment strategies. This article is protected by copyright. All rights reserved.
PMID: 32068318 [PubMed - as supplied by publisher]

Source: Cell Biology International - February 17, 2020 Category: Cytology Authors: Shiri Heris R, Safaroghli-Azar A, Yousefi AM, Hamidpour M, Bashash D Tags: Cell Biol Int Source Type: research