Exploratory meta-analysis on dose-related efficacy and complications of rhBMP-2 in anterior cervical discectomy and fusion: 1,539,021 cases from 2003 to 2017 studies

ConclusionsrhBMP-2 chosen in ACDF offered not only higher fusion, but also higher complication rate with more dysphagia and wound infections than non-rhBMP-2. To gain the efficacy and safety, rhBMP-2 dosing recommendations for ACDF would be better <0.7 mg/ level. Moreover, rhBMP-2 may be an option to improve nonunion in high risk of multi-level ACDF.
Source: Journal of Orthopaedic Translation - Category: Orthopaedics Source Type: research