SIRT1 and aging related signaling pathways

Publication date: Available online 19 February 2020Source: Mechanisms of Ageing and DevelopmentAuthor(s): Cui Chen, Min Zhou, Yuchen Ge, Xiaobo WangAbstractAging is a biological phenomenon in which the structure and function of organisms declining with the increasing of age. It has become a major risk factor of human diseases, including diabetes, cancers, cardiovascular diseases and neurodegenerative diseases. Silencing information regulator 2 related enzyme 1(sirtuin1, SIRT1) is an NAD+-dependent deacetylase, which has been reported to be involved in the regulation of cellular senescence and aging. The expression of SIRT1 is diminished with aging in mice. By contrast, increased expression of SIRT1 is sufficient to extend lifespan in yeast, caenorhabditis elegans and mice. In this review, the relationship between SIRT1 and aging and various signaling networks associated with aging, including NF-κB, AMPK, mTOR, P53, PGC1α, and FoxOs will be discussed. Meanwhile, the potential therapeutic strategies of targeting SIRT1 to anti-aging are also addressed.
Source: Mechanisms of Ageing and Development - Category: Geriatrics Source Type: research

Related Links:

U.S. health regulators are telling five drugmakers to recall versions of a popular diabetes drug due to contamination with an ingredient linked to cancer
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news
FRIDAY, May 29, 2020 -- A recall of the widely used diabetes drug metformin was announced by drug maker Apotex due to possible high levels of N-Nitrosodimethylamine (NDMA), which is believed to cause cancer in people. The recall for all lots of...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
When Eric Freeland, 34, started coughing at the end of March, he didn’t think much of it. But when his symptoms grew worse, Freeland’s mother began to worry. Freeland is a Native American living with his family in the Navajo Nation in the southwestern U.S., where access to healthcare is limited. He is also diabetic, putting him at greater risk to the coronavirus. When Freeland’s breathing became short and stuttered, his mother drove him to the nearest hospital where within minutes of arriving, he lost consciousness. He awoke three weeks later, hooked up to a ventilator, from a medically induced coma. &l...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 feature Londontime Source Type: news
Publication date: Available online 28 May 2020Source: Nutrition, Metabolism and Cardiovascular DiseasesAuthor(s): Ye-Seul Kim, Eun-A. Choi, Jae-woo Lee, Yonghwan Kim, Hyo-Sun You, Ye-Eun Han, Hyeong-Seop Kim, Yoon-Jong Bae, Hee-Taik Kang, Joungyoun Kim
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
Basel, 29 May 2020 - Roche (SIX: RO, ROG; OTCQX: RHHBY) today presented updated data from the pivotal phase III ALEX study, showing an increased five-year survival rate with Alecensa ® (alectinib), compared with crizotinib, in people living with anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC). These data confirm the longer-term efficacy of Alecensa already demonstrated across three phase III clinical trials. Full findings were presented at the ASCO2 0 Virtual Scientific Programme, on 29 May 2020.“These data further support Alecensa as the standard of care for people with metastatic AL...
Source: Roche Media News - Category: Pharmaceuticals Source Type: news
The U.S. Food and Drug Administration (FDA) said on Thursday it has recommended five pharmaceutical firms to voluntarily recall their diabetes drug metformin after the agency found high levels of a possible cancer-causing impurity in some versions of the medication.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
ConclusionsT2DM patients with cancers incurred greater medical costs in the diagnosis, ensuing, and mortality years than T2DM patients without cancers.
Source: Journal of Diabetes Investigation - Category: Endocrinology Authors: Tags: ORIGINAL ARTICLE Source Type: research
British Journal of Cancer, Published online: 29 May 2020; doi:10.1038/s41416-020-0910-yThe association of diabetes with risk of prostate cancer defined by clinical and molecular features
Source: British Journal of Cancer - Category: Cancer & Oncology Authors: Source Type: research
AbstractPurpose of ReviewTo review the clinical evidence of the effect of aspirin as primary prevention for patients with diabetes mellitus and in healthy elderly.Recent FindingsTwo trials were performed to study these two patient populations: ASCEND showed that the use of low-dose aspirin in persons with diabetes, who did not have prior cardiovascular disease, led to a lower risk of cardiovascular events than placebo (8.5% vs 9.6%, rate ratio 0.88, 95% CI 0.79 –0.97;p = 0.01). However, it showed a similar magnitude of increased risk of major bleeding among the aspirin group compared with placebo (4.1% ...
Source: Current Cardiology Reports - Category: Cardiology Source Type: research
ConclusionsIn our study, besides the known dosimetric factors, DM was found to be the most important risk factor causing RP development in multivariate analysis and RPA.The risk is tripled compared to patients without DM.
Source: The Clinical Respiratory Journal - Category: Respiratory Medicine Authors: Tags: ORIGINAL ARTICLE Source Type: research
More News: Brain | Cancer | Cancer & Oncology | Cardiology | Cardiovascular | Diabetes | Endocrinology | Geriatrics | Heart | Neurology