GSE110349 Increased intron retention is a post-transcriptional signature associated with progressive ageing and Alzheimer ’s disease
Contributors : Chin-Tong Ong ; Swarnaseetha AdusumalliSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterIntron retention (IR) may affect gene expression and protein functions during development and age-onset diseases. However, it remains unclear if IR undergoes spatial or temporal changes during different stages of ageing or neurodegenerative disorders like Alzheimer ’s disease (AD). By profiling mRNA species across different ages of Drosophila heads, we observed significant increase in the level of IR of many conserved genes as animals aged. Interestingly, distinct sets of genes are affected at different stages of adult fly life with IR occurring at several A D-associated genes in old adult. This suggests that alteration of proper protein functions by IR during ageing may lead to AD pathogenesis. Consistent with this notion, analyses of healthy human ageing brains and different AD datasets revealed similar increased aberrant IR activities in many AD-cur ated genes. Taken together, our data suggest that increase IR during ageing may be the driver for late-onset sporadic AD.
Yale ’s Dr. Le Zhang and Dr. Stephen Strittmatter are working to uncover sex-specific differences in of Alzheimer’s disease by studying individual cells.
Condition: Alzheimer Disease Intervention: Device: NEUROLITH Sponsors: Storz Medical AG; Rheintalklinik Completed
FRIDAY, April 3, 2020 -- The coronavirus pandemic will put extra stress on caregivers of loved ones with dementias, so the Alzheimer's Foundation of America offers some advice. " Reducing stress is always important for caregivers, and even more so...
(University of Barcelona) An article published in the Journal of Medicinal Chemistry shows a new family of molecules with high affinity to join imidazoline receptors, which are altered in the brain of those patients with neurodegenerative diseases such as Alzheimer's, Parkinson's and Huntington's. According to the preclinical study, the merge of these specific ligands to I2 receptors improves cognitive skills and some biomarkers which are indicators of brain neurodegenerative processes in murine models.
Alzheimer ’s disease (AD) is one of the leading causes of death in the US and there is no validated drugs to stop, slow or prevent AD. Despite tremendous effort on biomarker discovery, existing findings are mos...
ConclusionThe metal ions imbalance induces A β and tau pathologies by directly or indirectly affecting multiple cellular/subcellular pathways, and the disrupted homeostasis can reversely aggravate the abnormalities of metal ions transportation/deposition. Therefore, adjusting metal balance by supplementing or chelating the metal ions may be p otential in ameliorating AD pathologies, which provides new research directions for AD treatment.
ConclusionsThese results encourage further studies on the enamide scaffold as potential drug candidates for the treatment of Alzheimer's and Parkinson's diseases.
To elucidate the key molecules, functions, and pathways that bridge mild cognitive impairment (MCI) and Alzheimer's disease (AD), we investigated open gene expression data sets. Differential gene expression profiles were analyzed and combined with potential MCI- and AD-related gene expression profiles in public databases. Then, weighted gene co-expression network analysis was performed to identify the gene co-expression modules. One module was significantly negatively associated with MCI samples, in which gene ontology function and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis showed that these genes ...
In conclusion, our work proposes a comprehensive systems pharmacology approach to explore the underlying therapeutic mechanism of KXS for the treatment of AD.