Andrographolide ameliorates oxidative stress, inflammation and histological outcome in complete Freund's adjuvant-induced arthritis.

CONCLUSIONS: Andrographolide acts as a protective agent for the treatment of complete freund's adjuvant induced rheumatoid arthritis by inhibiting lipid peroxidation and nitrite/nitrate levels in a dose-dependent manner, enhancing antioxidant enzyme activity, reducing levels of chemokines and inflammatory factors, preventing neutrophil accumulation and infiltration.
PMID: 32061742 [PubMed - as supplied by publisher]

Source: Chemico-Biological Interactions - February 12, 2020 Category: Molecular Biology Authors: Luo S, Li H, Liu J, Xie X, Wan Z, Wang Y, Zhao Z, Wu X, Li X, Yang M, Li X Tags: Chem Biol Interact Source Type: research