A Mail Audit Independent Peer Review System for Dosimetry Verification of a Small Animal Irradiator.

A Mail Audit Independent Peer Review System for Dosimetry Verification of a Small Animal Irradiator. Radiat Res. 2020 Feb 18;: Authors: Gronberg MP, Tailor RC, Smith SA, Kry SF, Followill DS, Stojadinovic S, Niedzielski JS, Lindsay PE, Krishnan S, Aguirre F, Fujimoto TN, Taniguchi CM, Howell RM Abstract Dedicated precision orthovoltage small animal irradiators have become widely available in the past decade and are commonly used for radiation biology research. However, there is a lack of dosimetric standardization among these irradiators, which affects the reproducibility of radiation-based animal studies. The purpose of this study was to develop a mail-based, independent peer review system to verify dose delivery among institutions using X-RAD 225Cx irradiators (Precision X-Ray, North Branford, CT). A robust, user-friendly mouse phantom was constructed from high-impact polystyrene and designed with dimensions similar to those of a typical laboratory mouse. The phantom accommodates three thermoluminescent dosimeters (TLDs) to measure dose. The mouse peer review system was commissioned in a small animal irradiator using anterior-posterior and posterior-anterior beams of 225 kVp and then mailed to three institutions to test the feasibility of the audit service. The energy correction factor for TLDs in the mouse phantom was derived to validate the delivered dose using this particular animal irradiation system. This feasibility study ind...
Source: Radiation Research - Category: Physics Authors: Tags: Radiat Res Source Type: research