Construction of N-halamine biocompatible multilayers onto BMP2 loaded titanium nanotubes for bacterial infection inhibition and osteogenic effect improvement

Publication date: Available online 19 February 2020Source: Materials LettersAuthor(s): Yang Jiao, Qian Liu, Jihua ChenAbstractClinically, non-desired osseointegration and bacterial-associated infection are responsible for the failure of titanium (Ti)-based implantation in orthopedic field. Herein, bone morphogenetic protein 2 (BMP2) loaded TiO2 nanotubes (TNT) arrays were fabricated on Ti substrates. Next, bioactive multilayer films of MA-modified gelatin (GelMA) and N-Cl modification poly (N, N’-methylene bis(acrylamide)) (PMAA-Cl) were deposited onto the BMP2-loaded TNT substrates with layer-by-layer (LBL) self-assembly technique. The prepared samples (LBL) presented excellent antibacterial property against the adhesion and growth of Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). Meanwhile, the obtained substrates have positive effect on the adhesion, proliferation and differentiation of osteoblast. Hence, this study presented a simple and effective approach for development of antibacterial Ti-based implants for potential orthopedic application.Graphical abstract
Source: Materials Letters - Category: Materials Science Source Type: research