Nutritional and environmental contributions to Autism Spectrum Disorders: Focus on nutrigenomics as complementary therapy.

Nutritional and environmental contributions to Autism Spectrum Disorders: Focus on nutrigenomics as complementary therapy. Int J Vitam Nutr Res. 2020 Feb 17;:1-19 Authors: Jaureguiberry MS, Venturino A Abstract The prevalence of autism spectrum disorders (ASD) has risen sharply in the last 30 years, posing a major public health concern and a big emotional and financial challenge for families. While the underlying causes remain to be fully elucidated, evidence shows moderate genetic heritability contribution, but heavy environmental influence. Over the last decades, modern lifestyle has deeply changed our eating, rest, and exercise habits, while exposure to air, water, and food chemical pollution has increased due to indiscriminate use of pesticides, food additives, adjuvants, and antibiotics. The result is a drastic change in the quality of our energy source input, and an overload for antioxidant and detoxification pathways that compromises normal metabolism and homeostasis. Current research shows high prevalence of food selectivity and/or food allergy among children with autism, resulting in essential micronutrient deficits that may trigger or aggravate physical and cognitive symptoms. Nutrigenomics is an emerging discipline that focuses on genotype-micronutrient interaction, and a useful approach to tailor low risk, personalized interventions through diet and micronutrient supplementation. Here, we review available literature addressing the role of mic...
Source: International Journal for Vitamin and Nutrition Research - Category: Nutrition Tags: Int J Vitam Nutr Res Source Type: research

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Conclusion The scale aims to identify the areas of eating behavior that are altered in individuals with ASD, allowing more specific therapy to be implemented. The tool could also be used to measure the effectiveness of treatment.
Source: Jornal Brasileiro de Psiquiatria - Category: Psychiatry Source Type: research
Immune dysfunction and abnormal immune response may be associated with certain mechanisms underlying autism spectrum disorder (ASD). The early evidence for this link was based on the increased incidence of ASD in children with a history of maternal infection during pregnancy. Observational studies show increased prevalence of immune-related disorders—ranging from atopy, food allergy, viral infections, asthma, primary immunodeficiency, to autoimmune disorders—in individuals with ASD and their families. Evidence of neuroglial activation and focal brain inflammation in individuals with ASD implies that the central...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
In this study we observed an association between allergic disease and communication skills development as assessed by the Ages and Stages Questionnaire (ASQ) communication score, as a proxy for ASD, among children who participated in the Vitamin D Antenatal Asthma Reduction Trial (VDAART). In particular, we observed significant associations between both a diagnosis of eczema at age 3 years (OR=1.87; confidence interval [CI]: 0.97-3.47; p=0.054) and a diagnosis of food allergy at age 6 years (OR=3.61; 95% CI: 1.18-9.85; p=0.015) with ASQ communication score. Plasma metabolomics analyses suggest that dysregulated tryptophan ...
Source: Brain, Behavior, and Immunity - Category: Neurology Authors: Tags: Brain Behav Immun Source Type: research
Conclusion In Table 1, an overview is presented of the complex roles of AAs described in this review regarding the microbiome-gut-immune-brain axis in ASD. Besides behavioral deficits, people with ASD are characterized by systemic inflammation, gastrointestinal immune-related disturbances and changes in the gut microbiota composition. Moreover, differences in levels of specific AAs in various body compartments, including the intestinal tract, blood, urine and brain have been reported in patients with ASD, as well as in rodent models for ASD. This review described that specific AAs can modulate the intestinal epithelial im...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Recent studies have shown an association between self-reported allergic diseases and autism spectrum disorder in children. However, associations with developmental delay (DD) and allergic sensitization have not yet been described. Here we report on the association between DD and allergic disease in a nationally-representative sample.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: P304 Source Type: research
CONCLUSIONS: This proof-of-concept study demonstrates the feasibility of TSO for the treatment of ASD, including a favorable safety profile, and moderate to large effect sizes for reducing repetitive behaviors and irritability. PMID: 30230399 [PubMed - as supplied by publisher]
Source: The World Journal of Biological Psychiatry - Category: Psychiatry Authors: Tags: World J Biol Psychiatry Source Type: research
(MedPage Today) -- Association persisted after controlling for other allergies
Source: MedPage Today Neurology - Category: Neurology Source Type: news
After the researchers controlled the data to account for other factors that might link these conditions, such as education, income and location, the odds that someone with an ASD would have a food allergy were more than twice that of someone without an ASD
Source: WebMD Health - Category: Consumer Health News Source Type: news
Food allergies are two-and-a-half times more common among children with autism than others, a University of Iowa study finds, adding evidence to the theory that autism is an autoimmune condition.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
FRIDAY, June 8, 2018 -- Common allergic conditions, especially food allergy, are associated with autism spectrum disorder (ASD) in children, according to a study published online June 8 in JAMA Network Open. Guifeng Xu, M.D., from the University of...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
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