miR-200b regulates cellular senescence and inflammatory responses by targeting ZEB2 in pulmonary emphysema

Volume 48, Issue 1, December 2020, Page 656-663 .
Source: Artificial Cells, Blood Substitutes, and Biotechnology - Category: Biotechnology Authors: Source Type: research

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DiscussionWTC workers with spirometric low FVC have higher QCT-measured WAP compared to those with normal spirometries, but did not differ in distal airway and emphysema measurements, independently of obesity, smoking, and other covariates.
Source: Lung - Category: Respiratory Medicine Source Type: research
In conclusion, when treating elderly men with a smoking history, physicians need to carefully examine the walls of cystic airspaces on CT for fetal adenocarcinoma.Key pointsSignificant findings of the study•Pulmonary high‐grade fetal adenocarcinoma may be associated with emphysematous bullae manifesting as cystic air spaces as shown by computed tomography.What this study adds•When scanning by computed tomography, physicians should carefully examine the pulmonary cystic airspace walls in elderly men with a smoking history.
Source: Thoracic Cancer - Category: Cancer & Oncology Authors: Tags: CASE REPORT Source Type: research
(Natural News) Chronic obstructive pulmonary disease (COPD) refers to a cluster of potentially fatal respiratory conditions. It is marked by breathlessness, inflammation, airway obstruction and significant bronchial damage. Many of the chronic respiratory diseases classified under COPD, such as emphysema and chronic bronchitis, are primarily caused by exposure to cigarette smoke. However, COPD can also...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
Conclusion: Combined minimally invasive VATS fissure stapling with bronchoscopic valve placement to induce lobar atelectasis appears safe and feasible in the swine model. Future research in humans using a combined procedure is needed to confirm safety and clinical efficacy.
Source: Journal of Bronchology and Interventional Pulmonology - Category: Respiratory Medicine Tags: Original Investigations Source Type: research
To the Editor We read with great interest the article by Paulin et al, who examined the association between long-term ozone exposure and the respiratory health of smokers, finding that higher ozone exposure was significantly associated with lower lung function and more emphysema and air trapping. The findings of this article underscore the need for enhanced meteorological monitoring on ground ozone concentrations as well as the need for early detection and targeted intervention of respiratory diseases in vulnerable members of society to reduce the escalating burden of respiratory diseases worldwide. However, from the viewp...
Source: JAMA Internal Medicine - Category: Internal Medicine Source Type: research
Bocchino Alpha-1-antitrypsin deficiency (AATd) is a hereditary disease, mainly characterized by early onset and the lower lobes’ predominant emphysema. Bronchiectasis is characterized by dilatation of the bronchial wall and a clinical syndrome whose features are a cough, sputum production and frequent respiratory exacerbations. In the literature, there are many papers concerning these two clinical entities, but there is still a lot of debate about a possible association between them, in particular about the frequency of their association and causal links. The aim of this short communication is to show the li...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Communication Source Type: research
ConclusionThoracoscopic surgery under local anesthesia can be the worthwhile definitive modality, among few remaining treatments, for highly fragile patients with SSP. Detecting air leakage directly and the presence of thin and transparent bullae without any other suspicious lesions can be clues for identifying culprit lesions.
Source: General Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
AbstractThe aim of our study is a retrospective evaluation of effectiveness and safety of Computed Tomography (CT)-guided radiofrequency ablation (RFA) therapy of primary and metastatic lung lesions in patients that cannot be considered surgical candidates. From February 2007 to September 2017, we performed 264 CT-guided ablation sessions on 264 lesions in 174 patients (112  M and 62 F; mean age, 68 years; range 36–83 years) affected by primary and metastatic lung lesions. The 45% of patients was affected by primary lung cancer, with size range lesion of 10–50 mm, and the 55% by metastatic l...
Source: Medical Oncology - Category: Cancer & Oncology Source Type: research
AbstractThe purpose of this study was to evaluate the added value of postmortem magnetic resonance imaging (MRI) compared to postmortem computed tomography (CT) and autopsy in cases of fatal hanging. In addition, the study analyzed the strengths of each examination method regarding typical injuries in these cases. We investigated a cohort of 25 decedents who underwent CT, MRI and autopsy. Two radiologists assessed all MR images of the head and neck as well as the corresponding CT images. The results were compared to autopsy findings by retrospectively analyzing the autopsy reports. Postmortem MRI revealed intramuscular hem...
Source: Forensic Science, Medicine, and Pathology - Category: Forensic Medicine Source Type: research
We report a case where serial follow-up chest computed tomography revealed progression of pulmonary lesions into confluent bilateral consolidation with lower lung predominance, thereby confirming COVID-19 pneumonia. Furthermore, complications such as mediastinal emphysema, giant bulla, and pneumothorax were also observed during the course of the disease. PMID: 32207255 [PubMed - as supplied by publisher]
Source: Korean Journal of Radiology - Category: Radiology Tags: Korean J Radiol Source Type: research
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