Electrochemical synthesis of α,α-dihaloacetophenones from terminal alkyne derivatives

Publication date: Available online 18 February 2020Source: Chinese Chemical LettersAuthor(s): Zhibin Li, Qi Sun, Peng Qian, Kangfei Hu, Zhenggen Zha, Zhiyong WangABSTRACTBy virtue of electrochemistry, a series of α,α-dihaloacetophenones were easily obtained with good to excellent yields. This electrochemical procedure was taken in a divided cell with constant current in aqueous media. The reaction can be carried out smoothly at room temperature under metal and oxidant free condition, which provides an eco-friendly synthesis for the α,α-dihaloacetophenone derivatives.Graphical abstractAn electrochemical synthesis of α,α-dihaloacetophenones from alkyne derivatives was developed by virtue of anodic oxidation. The reaction can be carried out smoothly at room temperature under metal and oxidant free condition in aqueous media, affording the α,α-dihaloacetophenones derivatives in good to excellent yield.

Source: Chinese Chemical Letters - February 19, 2020 Category: Chemistry Source Type: research