Dysfunctional HDL takes its  Toll on the endothelial glycocalyx

Patients with end-stage renal disease have a high risk of dying from cardiovascular disease that cannot be explained solely by traditional cardiovascular disease risk factors. Hesse et  al. suggest that dysfunctional high-density lipoprotein cholesterol generated in patients with end-stage renal disease causes endothelial glycocalyx degradation. Glycocalyx degradation may represent one of the earliest insults leading to atheroma formation, and so this work suggests a novel link b etween renal failure and cardiovascular disease.

Source: Kidney International - February 19, 2020 Category: Urology & Nephrology Authors: Matthew J. Butler Tags: Commentary Source Type: research