Measuring glomerular filtration rate with iohexol plasma disappearance: blood collection duration is essential for accurate glomerular filtration rate determinations

Recently, Rowe et  al. reported the biological variation of measured glomerular filtration rate (mGFR) and estimated glomerular filtration rate (eGFR) for chronic kidney disease in 20 patients.1 An examination of their iohexol plasma disappearance mGFR protocol shows that the authors administered 5 ml of Omnipaque 2 40 (518 g/l of iohexol; GE Healthcare [Little Chalfont, Buckinghamshire, UK]) and acquired blood specimens at 3 time points with the longest collection time duration of 240 minutes. We acknowledge that there is currently no standardized protocol for an iohexol plasma disappearance procedure for the purpose of mGFR.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Letter to the Editor Source Type: research