Lobar distribution of non-emphysematous gas trapping and lung hyperinflation in chronic obstructive pulmonary disease

ConclusionNon-emphysematous gas trapping in the upper and lower lobes has a distinct physiological effect, especially in COPD with minimal emphysema. This local evaluation might allow sensitive detection of changes in lung hyperinflation in COPD.
Source: Respiratory Investigation - Category: Respiratory Medicine Source Type: research

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ConclusionRadiological findings of particular interest included the high burden of opacities observed and the presence of RCS ‐associated features in the majority of subjects. Radiologists are at the front line in occupational lung disease screening/diagnosis and must be aware of the imaging spectrum.
Source: Journal of Medical Imaging and Radiation Oncology - Category: Radiology Authors: Tags: Medical Imaging —Original Article Source Type: research
Publication date: Available online 3 February 2020Source: Academic RadiologyAuthor(s): Kum Ju Chae, Jiwoong Choi, Gong Yong Jin, Eric A. Hoffman, Archana T. Laroia, Margaret Park, Chang Hyun LeeObjectivesThe purpose of this study was to investigate regional air volume changes at the acinar scale of the lung in chronic obstructive pulmonary disease (COPD) patients using an image registration technique.Materials and MethodsThirty-four emphysema patients and 24 subjects with normal chest CT and pulmonary function test (PFT) results were included in this retrospective study for which informed consent was waived by the institut...
Source: Academic Radiology - Category: Radiology Source Type: research
R, Diaz AA Abstract BACKGROUND: Mucous exudates occluding the lumen of small airways are associated with reduced lung function and mortality in COPD subjects; however, luminal plugs in large airways have not been widely studied. We aimed to examine the associations of chest computed tomography (CT)-identified luminal plugging with lung function, health-related quality of life, and COPD phenotypes. METHODS: We randomly selected 100 smokers without COPD and 400 with COPD from the COPDGene Study. Luminal plugging was visually identified on inspiratory CT scans at baseline and five-year follow-up. The relationsh...
Source: Chest - Category: Respiratory Medicine Authors: Tags: Chest Source Type: research
Introduction: Emphysema is defined on pathology, however it can also be identified on CT scan where it has been associated with increased all-cause mortality in those with and without COPD. Determinants of emphysema progression in the general population have not been extensively studied.Methods: A large population-based study enrolled participants 45-84 years old in 2000-02 in six U.S. cities. The percent of emphysema-like lung was defined on outside-air corrected computed tomoraphy (CT) scans as the area with attenuation below -950 Hounsfield Units. Percent emphysema was measured up to 5 times in each participant on cardi...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Epidemiology Source Type: research
Conclusion: CT-identified mucus plugging has a prognostic value in smokers. Mucus plugging might be a distinct imaging phenotype.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Monitoring airway disease Source Type: research
Conclusions: Various CT parameters are independent predictors of COPD severity.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Monitoring airway disease Source Type: research
Conclusion: A COPD/emphysema based strategy for the selection of LCS candidates is feasible. The prevalence of LC in our high risk cohort was 2.31%. 64% of patients were operable, and median survival at 4 years was 94%.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung cancer Source Type: research
Introduction: Bronchiectasis has been classified as a comorbidity of COPD patients, associated with frequent exacerbations and severity of airflow limitation. In our study, we investigated the prevalence and characteristics of bronchiectasis in the lung cancer screening (LCS) program.Material and methods: A transversal study was performed. From 2014 until September 2018, 1005 patients were included in our LSC program. Of these, 949 had low-dose computed tomography (LDCT). The subjects met the NLST criteria (age between 55 and 75 who have a 30 pack-year smoking history and are currently smoking or have quit within the past ...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung cancer Source Type: research
In this study, we aimed to examine alveolar dimensions of QES using the apparent diffusion coefficient (ADC).Methods and Materials: Using texture patterns of emphysematous regions and spatial localization on CT scans (n=2,922), 6 distinct QES were discovered in smokers with COPD as well as controls sampled from population-based studies. Hyperpolarized helium (3He) MRI ADC was measured in a sub-sample (n=50). The associations between ADC and QES were evaluated in generalized estimating equations with adjustment for age, sex, race, height, weight, smoking status, pack-years, % predicted FEV1 and % emphysema on CT.Results: Ap...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Imaging Source Type: research
Background: An upregulation of the B cell compartment is present in the COPD lungs, together with increases in the number of B cell-rich lymphoid follicles (LFs), and in the levels of B cell products such as B cell Activation Factor (BAFF). We hypothesize that this exaggerated B cell response observed in COPD is associated with the extent of computed tomography (CT)-defined emphysema independently of the airflow limitation and thus GOLD stage.Methods: We performed immunofluorescence stainings for B cells, BAFF, CD138 (plasmacells), CD10 (immature B cells), CD24 (naive B cells), CD27 (memory B cells), IgD and IgG on lung se...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Molecular pathology and funct. genomics Source Type: research
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