RadioPathomics Artificial Intelligence Model to Predict Tumor Regression Grading in Locally Advanced Rectal Cancer

Condition:   Rectal Cancer Intervention:   Sponsors:   Sixth Affiliated Hospital, Sun Yat-sen University;   The Third Affiliated Hospital of Kunming Medical College.;   Sir Run Run Shaw Hospital Recruiting
Source: - Category: Research Source Type: clinical trials

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Conditions:   Locally Advanced Rectal Cancer;   Abdominoperineal Resection Intervention:   Sponsors:   Oslo University Hospital;   University of Oslo Recruiting
Source: - Category: Research Source Type: clinical trials
Various tumor characteristics might lead to inaccurate local MRI-defined stage of rectal cancer and the purpose of this study was to explore the clinicopathological factors that impact on the precision pre-tre...
Source: BMC Cancer - Category: Cancer & Oncology Authors: Tags: Research article Source Type: research
Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
Condition:   Rectal Cancer Intervention:   Procedure: Empty Bladder planning CT scan and CBCTs Sponsor:   Institut Cancerologie de l'Ouest Not yet recruiting
Source: - Category: Research Source Type: clinical trials
This study aimed to explore the prognostic impact of lymph node regression grade (LRG) in patients with locally advanced rectal cancer (LARC) following NCRT and radical surgery and develop a predictive nomogram for disease-free survival (DFS).MethodsLARC patients undergoing NCRT and radical surgery between 2013 and 2014 were enrolled and divided into LRG low ( ≤ 2), middle (3–9), and high (≥ 10) groups. Clinicopathological characteristics and survival outcomes were compared. Predictors for DFS were identified by Cox regression analysis, and a nomogram was constructed.ResultsA total of 257 LAR...
Source: Journal of Gastrointestinal Surgery - Category: Surgery Source Type: research
In this study, we performed a gene expression study using formalin-fixed paraffin-embedded (FFPE) tumor biopsy samples from 156 LARC patients (training cohort n = 60; validation cohort n = 96); we identified the nine-gene signature (FGFR3, GNA11, H3F3A, IL12A, IL1R1, IL2RB, NKD1, SGK2, and SPRY2) that distinctively differentiated responders from non-responders in the training cohort (accuracy = 86.9%, specificity = 84.8%, sensitivity = 81.5%) as well as in an independent validation cohort (accuracy = 81.0%, specificity = 79.4%, sensitivity = 82.3%). The signature was independent of all pathological and clinical features an...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Authors: Votava J, Kachlik D, Hoch J Abstract Total mesorectal excision (TME) was first described 40 years ago by Richard Heald. The purpose of this article is to point out importance of this surgical procedure. Starting from first attempts to surgically cure rectal carcinoma in the 19th century through Miles' operation at the beginning of the 20th century results were not satisfactory due to high number of local recurrences after resections for rectal cancer. Progress in surgical technique and knowledge of anatomy and embryology of the rectum led to development of TME. Principle of TME is surprisingly simple: remo...
Source: Acta Chirurgica Belgica - Category: Surgery Tags: Acta Chir Belg Source Type: research
DR DANIEL ALBO (Augusta, GA): There is a significant shift in the presentation of colorectal cancer in population-based studies. Currently, 3 of 10 rectal cancers are actually diagnosed before the age of 50 years. I noticed that you focused your study on colon cancer patients. Did you notice a significant number of these patients who present with rectal disease as a primary site, in particular, the carcinomatosis data set? Those are known to have an even more aggressive prognostic factor of outcomes.
Source: Journal of the American College of Surgeons - Category: Surgery Tags: Southern surgical association article Source Type: research
Condition:   Cancer of Rectum Intervention:   Diagnostic Test: Analysis of cfDNA Sponsors:   Hospital Pedro Hispano;   Diogo Melo Pinto, MD, Hospital Pedro Hispano;   Sara Rodrigues, MD, Centro Hospitalar de São João;   Silvestre Carneiro, PhD, Centro Hospitalar de São João;   Pedro Currais, MD, IPO Lisboa;   Isadora Rosa, MD, IPO Lisboa;   Isabel Priet o, PhD, Hospital La Paz, Madrid Recruiting
Source: - Category: Research Source Type: clinical trials
ConclusionsAL may negatively impact cancer-specific outcomes after curative rectal cancer surgery and could be considered an independent negative prognostic factor.
Source: Techniques in Coloproctology - Category: Surgery Source Type: research
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