Radiomics-based Artificial Intelligence System to Predict Neoadjuvant Treatment Response in Rectal Cancer

Condition:   Rectal Cancer Intervention:   Sponsors:   Sixth Affiliated Hospital, Sun Yat-sen University;   The Third Affiliated Hospital of Kunming Medical College.;   Sir Run Run Shaw Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research
Neoadjuvant chemotherapy and short-course radiotherapy followed by resection has been gaining recognition in the treatment of rectal cancer. Avelumab is a fully human immunoglobulin that binds Programmed Death...
Source: Radiation Oncology - Category: Cancer & Oncology Authors: Tags: Research Source Type: research
Operation is the standard of care after neoadjuvant chemoradioterapy. Therefore a nonoperative management (W&W) has been proposed as an option for patients who achieve a complete clinical response by exclusive chemoradiotherapy. This approach is still investigational and we compared outcomes between patients in this group with those who had a complete pathologic response after surgical resection to address whether W&W approach has an oncologic efficacy in terms of overall survival, disease-free survival, local relapse, and distant relapse, and also whether it should be implemented in clinical practice.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Colon and rectal surgery Source Type: research
Neoadjuvant chemoradiotherapy has become the standard treatment for locally advanced rectal cancer. Watchful waiting (WW) strategy was used in a few patients with clinical complete response (cCR).
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Colon and Rectal Surgery Source Type: research
Previous studies have shown high rates of positive circumferential resection margin (CRM) after proctectomy in the US. We sought to explore whether widespread deployment of neoadjuvant therapy has impacted the national rate of positive CRM.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Colon and Rectal Surgery Source Type: research
We present a cost-effectiveness analysis of WW protocols vs abdominal-perineal-resection (APR)/low-anterior-resection (LAR) for rectal cancer patients with complete clinical response after chemoradiation.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Colon and rectal surgery Source Type: research
Publication date: Available online 28 September 2020Source: Practical Radiation OncologyAuthor(s): Fiore Michele, Greco Carlo, Coppola Roberto, Caricato Marco, Caputo Damiano, Trecca Pasquale, Floreno Barnaba, Rinaldi Carla Germana, Ippolito Edy, Capolupo Gabriella Teresa, Grippo Raffaele, Beomonte Zobel Bruno, D’Angelillo Rolando Maria, Trodella Lucio, Ramella Sara
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research
ConclusionsOur case-matched study suggested that a TD tube does not reduce the AL rate after laparoscopic sphincter-saving surgery for rectal cancer.
Source: Techniques in Coloproctology - Category: Surgery Source Type: research
Conditions:   Rectal Cancer Stage;   Oesophageal Cancer Interventions:   Radiation: CRT;   Radiation: SCPRT;   Radiation: CROSS Protocol;   Diagnostic Test: PD-L1 PET Sponsors:   Johannes Laengle, MD, PhD;   Christian Doppler Laboratory Applied Metabolomics Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
More News: Cancer | Cancer & Oncology | Hospitals | Neoadjuvant Therapy | Rectal Cancers | Research