Radiation Associated Secondary Malignancies in BRCA Mutation Carriers Treated for Breast Cancer

Radiation therapy (RT), a standard Breast Cancer (BC) treatment modality, is associated with a small increased risk of in-field second primary malignancy (SPM). SPM rates following RT in BRCA mutation carriers, have rarely been reported. An elevated risk of SPM would impact the safety of breast conservation for early BC or prophylactic radiation as a method of prevention. We analyzed a population of BRCA carriers irradiated for BC to determine if there is an elevated rate of SPM.

Source: International Journal of Radiation Oncology * Biology * Physics - February 17, 2020 Category: Radiology Authors: S. Schlosser, R. Rabinovitch, Z. Shatz, S. Galper, I. Shahadi-Dromi, S. Finkel, G. Jacobson, A. Rasco, E. Friedman, Y. Laitman, E. Evron, R. Bernstein, I. Weiss, M. Sklair- Levy, M.A. Ben-David Source Type: research