Automatic opportunistic osteoporosis screening using low-dose chest computed tomography scans obtained for lung cancer screening

ConclusionThe proposed deep learning-based system demonstrated the potential to automatically perform opportunistic osteoporosis screening using LDCT scans obtained for lung cancer screening.Key Points• Osteoporosis is a prevalent but underdiagnosed condition that can increase the risk of fracture.• A deep learning-based system was developed to fully automate bone mineral density measurement in low-dose chest computed tomography scans.• The developed system achieved high accuracy for automatic opportunistic osteoporosis screening using low-dose chest computed tomography scans obtained for lung cancer screening.
Source: European Radiology - Category: Radiology Source Type: research

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(Natural News) The shoulder blades or scapulae are triangular bones located on the upper back. The scapulae serve many functions including shoulder rotation and spinal support. Pain along this region is often caused by poor posture and muscle strain. However, serious conditions, such as cardiovascular disease, lung cancer and osteoporosis, can also affect the shoulders....
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
This study provides comprehensive information about the structures, formation, and types of the oxysterols even when involved in certain disease states, focusing on their effects on metabolism and linkages with these diseases. The role of specific oxysterols as mediators in various disorders, such as degenerative (age-related) and cancer-related disorders, have now become clearer. Oxysterol levels may be employed as suitable markers for the diagnosis of specific diseases or in predicting the incidence rate of diseases, such as diabetes mellitus, Alzheimer's disease, multiple sclerosis, osteoporosis, lung cancer, breast can...
Source: Current Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Med Chem Source Type: research
Authors: Manavi KR, Alston-Mills BP, Thompson MP Abstract Tobacco usage kills more than 8 million people a year. Approximately 7 million of those deaths are the result of direct tobacco use, while approximately 1.2 million are the result of non-smokers being exposed to second-hand smoke. About 200 million of the world's one billion smokers are women and usage among women is increasing in some countries. Nicotine from smoking tobacco, specifically its metabolite cotinine, has negative effects on human health causing lung cancer, COPD and non-respiratory problems. Over a billion people worldwide are Vitamin D defici...
Source: International Journal for Vitamin and Nutrition Research - Category: Nutrition Tags: Int J Vitam Nutr Res Source Type: research
e;már J, Hegedűs B, Garay T Abstract Bisphosphonates, despite proven antitumor effect in vitro in many tumor types, are currently used only for treatment of osteoporosis and bone metastasis. Colorectal cancer is the third most commonly diagnosed type of cancer and lacks targeted therapy for RAS or RAF mutation carrying cases. A new lipophilic bisphosphonate showed promising results in lung cancer models, but their effect on colorectal cancer cells was not investigated excessively. Antitumor effects and impact on RAS-related signalization of zoledronic acid (ZA) and a lipophilic bisphosphonate (BPH1222) wer...
Source: Pathology Oncology Research - Category: Pathology Authors: Tags: Pathol Oncol Res Source Type: research
In this study, we hypothesized that moderately and chronically reducing ACh could attenuate the deleterious effects of aging on NMJs and skeletal muscles. To test this hypothesis, we analyzed NMJs and muscle fibers from heterozygous transgenic mice with reduced expression of the vesicular ACh transporter (VAChT), VKDHet mice, which present with approximately 30% less synaptic ACh compared to control mice. Because ACh is constitutively decreased in VKDHet, we first analyzed developing NMJs and muscle fibers. We found no obvious morphological or molecular differences between NMJs and muscle fibers of VKDHet and contro...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
THURSDAY, Sept. 12, 2019 -- CT lung cancer screening can detect other serious smoking-related conditions, such as heart disease, osteoporosis and emphysema, researchers say. Medical experts consider lung cancer screening an effective way to detect...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
About 77 percent of patients who received CT scans for lung cancer were diagnosed with cardiovascular disease, emphysema or osteoporosis, according to a new study showing the same scan can screen for additional diseases.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news
New diagnoses of CVD, emphysema, osteoporosis identified, often are linked to adverse events
Source: Pulmonary Medicine News - Doctors Lounge - Category: Respiratory Medicine Tags: Cardiology, Endocrinology, Family Medicine, Geriatrics, Internal Medicine, Oncology, Orthopedics, Pulmonology, Radiology, Rheumatology, Journal, Source Type: news
Abstract Starting from their role exerted on osteoblast and osteoclast differentiation and activity pathways, microRNAs (miRNAs) have been recently identified as regulators of different processes in bone homeostasis. For this purpose, in a recent review, we highlighted, as deregulated miRNAs could be involved in different bone diseases such as osteoporosis. In addition, recent studies supported the concept that osteoporosis-induced bone alterations might offer a receptive site for cancer cells to form bone metastases, However, to date, no data on specific-shared miRNAs between osteoporosis and bone metastases have...
Source: Cellular and Molecular Life Sciences : CMLS - Category: Cytology Authors: Tags: Cell Mol Life Sci Source Type: research
Authors: Roslan Z, Muhamad M, Selvaratnam L, Ab-Rahim S Abstract Low-density lipoprotein receptor (LDLR) has been an object of research since the 1970s because of its role in various cell functions. The LDLR family members include LRP5, LRP6, and LRP8. Even though LRP5, 6, and 8 are in the same family, intriguingly, these three proteins have various roles in physiological events, as well as in regulating different mechanisms in various kinds of cancers. LRP5, LRP6, and LRP8 have been shown to play important roles in a broad panel of cancers. LRP5 is highly expressed in many tissues and is involved in the modulation...
Source: Journal of Oncology - Category: Cancer & Oncology Tags: J Oncol Source Type: research
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