Implication of cell migration inducing hyaluronidase 1 (CEMIP) in hyaluronan degradation by synovial fibroblasts in patients with knee osteoarthritis

Cell migration inducing hyaluronidase 1 (CEMIP), also known as hyaluronan (HA)-binding protein involved in HA depolymerization (HYBID), plays a role in HA degradation. Cell migration inducing hyaluronidase 2 (CEMIP2), also known as transmembrane protein 2 (TMEM2), possessing a sequence similarity with HYBID, is reported as a hyaluronidase in mice. However, the expression of these molecules in osteoarthritic synovium and their involvement in HA degradation in synovial fluid (SF) from patients with knee osteoarthritis remain elusive.

Source: American Journal of Pathology - February 17, 2020 Category: Pathology Authors: Jun Shiozawa, Susana de Vega, Mehmet Zeynel Cilek, Chiho Yoshinaga, Tomomi Nakamura, Shinya Kasamatsu, Hiroyuki Yoshida, Haruka Kaneko, Muneaki Ishijima, Kazuo Kaneko, Yasunori Okada Tags: Regular Article Source Type: research