Massively elevated creatine kinase levels in antihistamine-induced rhabdomyolysis.

Massively elevated creatine kinase levels in antihistamine-induced rhabdomyolysis. Proc (Bayl Univ Med Cent). 2020 Jan;33(1):44-46 Authors: Ramakrishna KN, Shah A, Martinez-Balzano CD Abstract Rhabdomyolysis is the destruction of skeletal muscle tissue with release of intracellular components into the circulation. Elevation of creatine kinase levels in serum is indicative of muscle damage and is associated with acute kidney injury. Antihistamines are a rare cause of nontraumatic rhabdomyolysis. Herein we describe a case of intentional ingestion of diphenhydramine resulting in rhabdomyolysis with subsequent elevation in creatine kinase levels exceeding 2 million IU/L. Aggressive intravenous volume expansion rapidly lowered creatine kinase levels and improved renal function. PMID: 32063765 [PubMed]
Source: Baylor University Medical Center Proceedings - Category: Universities & Medical Training Authors: Tags: Proc (Bayl Univ Med Cent) Source Type: research