Thromboembolism prophylaxis during L-asparaginase therapy in acute lymphoblastic leukemia – time to reconsider current approaches?

Acute Lymphoblastic Leukemia (ALL) is the commonest malignancy in childhood with a second incidence peak in adulthood. Improvements in pediatric therapy including the addition of L-asparaginase (L-ASP) have enabled cure rates in excess of 90% to be achieved in children. More recently L-ASP-containing pediatric protocols are being used to treat younger adults with ALL and have improved survival by approximately 2-fold. However, a toxicity associated with L-ASP-containing therapy in ALL is venous thromboembolism (VTE) which is associated with significant morbidity in this patient population and results in interruptions in L-ASP therapy that can impact on survival outcomes.

Source: Thrombosis Research - February 17, 2020 Category: Hematology Authors: J. Fulcher, M. Carrier Tags: Short Review Source Type: research