Factors Associated with Vitamin D Levels in Patients with Chronic Obstructive Pulmonary Disease in Combination with Renal Dysfunction

AbstractThe goal of the study was to analyze factors associated with vitamin D levels in patients diagnosed with chronic obstructive pulmonary disease (COPD) in combination with the early stages of renal dysfunction. The study covered 338 patients with first- and second-degree COPD (including 66.9% men with a mean age of 69.4 ± 6.1 years and an average COPD duration of 18.5 ± 4.1 years and 33.1% women with a mean age of 64.8 ± 7.3 years and an average COPD duration of 12.1 ± 5.1 years). All patients were diagnosed with first- and second-degree chronic kidney disease (CKD). In addition to general clinical examinations , potential risk factors for vitamin D deficiency were assessed in all patients. In multiple regression with step-by-step inclusion of signs, the following identified factors made a significant contribution to the levels of vitamin D synthesis in patients with COPD in combination with the early stag es of renal dysfunction: annualized relapse rate of COPD (3 (2–4), β = –0.932,p = 0.003), smoking index (SI) (44 (15 –87), β = –0.038,p = 0.006), fibrinogen level (5 (3 –7), β = –0.413,p = 0.016), GFR (74.9 (68.4 –89), β = –0.119,p = 0.041), insolation (94.5 (38.5 –152), β = 0.026,p = 0.0008), the total score on the GDS scale (9 (8 –11), β = –0.536,p = 0.014).R2 for this model was 0.87. BMI made a significant contribution to the level of vitamin D synthesis at the stage of inclusion in multivariate analysis, but the connection weakened ...
Source: Advances in Gerontology - Category: Geriatrics Source Type: research