Role of mTOR and VEGFR Inhibition in Prevention of Metastatic Tumor Growth in the Spine

Conclusion: Both, the mTOR inhibitor everolimus as well as antiangiogenetic effects by the VEGFR inhibitor axitinib showed potential to prevent and retard formation of symptomatic spinal metastases. However, the therapeutic efficacy was only mild in this experimental model.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research