Efficacy of Oxaliplatin/5-Fluorouracil/Capecitabine-Cetuximab Combination Therapy and Its Effects on K-Ras Mutations in Advanced Colorectal Cancer.

Efficacy of Oxaliplatin/5-Fluorouracil/Capecitabine-Cetuximab Combination Therapy and Its Effects on K-Ras Mutations in Advanced Colorectal Cancer. Med Sci Monit. 2020 Feb 16;26:e919031 Authors: Wei L, Chen J, Wen J, Wu D, Ma X, Chen Z, Huang J Abstract BACKGROUND The aim of this study was to perform an accurate exploration on the efficacy of oxaliplatin/5-fluorouracil/capecitabine-cetuximab combination therapy and its effects on K-Ras mutations in advanced colorectal cancer. MATERIAL AND METHODS Among 96 patients who suffered metastatic colorectal cancer without mutated K-Ras, 41 patients who were receiving treatment with oxaliplatin/5-fluorouracil/capecitabine and administered cetuximab as the initial treatment comprised the observation group; the remaining 55 patients receiving cetuximab as an alternative treatment comprised the control group. RESULTS The observation group experienced significantly higher objective response rates (ORRs), and disease control rates (DCRs), than the control group (P
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research

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Publication date: Available online 24 September 2020Source: Seminars in Cancer BiologyAuthor(s): Erik Schadde, J. Grunhagen, Kees Verhoef, Lucyna Krzywon, Peter Metrakos
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
Condition:   Colorectal Cancer Metastatic Interventions:   Drug: Capecitabine;   Drug: Bevacizumab;   Drug: Trifluridine/Tipiracil Sponsor:   Gruppo Oncologico del Nord-Ovest Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Huang MY, Lee HH, Huang CW, Huang CM, Ma CJ, Yin TC, Tsai HL, Chai CY, Chen YT, Wang JY Abstract Colorectal cancer (CRC) of the clinical tumor stage T4b (cT4b) refers to advanced tumors with direct invasion of adjacent structures and the tumors are considered unresectable. Despite advancements in aggressive surgery and combination chemotherapy, the prognosis of cT4b CRC remains poor. Optimizing the therapeutic sequence administered to patients with cT4b CRC to improve clinical outcomes is crucial. In the present study, patients with unresectable cT4b and nodal stage N1-2 CRC were investigated at a single i...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
In conclusion, the present study indicated that RRBP1 was associated with bladder cancer migration, invasion and prognosis, and CCR7 might serve a role in the process. PMID: 32963609 [PubMed]
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
This study aims to assess the expression profiles of MUC1 and MUC5AC and their implications in colorectal carcinogenesis. MATERIALS AND METHODS: We conducted a retrospective study of 202 patients who underwent colorectal cancer surgery. The expression of MUC1 and MUC5AC was investigated by immunohistochemistry and reverse transcription-polymerase chain reaction (RT-PCR). Statistical analysis of mucins expression pattern along with the patients? clinicopathological criteria was performed by the chi-square test, survival curves were plotted using the Kaplan-Meier product-limit method, and differences between the survival...
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
Authors: Akhmaltdinova L, Sirota V, Zhumaliyeva V, Babenko D, Kadyrova I, Tauesheva Z, Taizhanova D, Ibraeva A, Maratkyzy M, Turmukhambetova A Abstract Colorectal cancer is a type of oncopathology widespread in Kazakhstan. The genetic component, as well as the possible etiopathogenetic mechanisms, is widely studied. One of the most promising areas is the study of diagnostic and prognostic possibilities of inflammatory biomarkers in patients with different degrees of tumor differentiation. The following biomarkers were included in the study panel: stem cell factor (SCF), vascular endothelial growth factor (VEGF), fi...
Source: International Journal of Inflammation - Category: Allergy & Immunology Tags: Int J Inflam Source Type: research
Abstract The prognostic role of the neutrophil-to-lymphocyte ratio (NLR) has been reported in colorectal cancer (CRC); however, its variation and corresponding predicative value in patients undergoing resection remain largely unknown. In the present study, data from 146 patients with CRC were retrospectively collected, optimal cut-off points for preoperative and postoperative low and high NLRs were set, and ΔNLR was calculated. Subsequently, patients were classified into low-low, low-high, high-low and high-high subgroups based on the cut-off points, and their progression-free survival (PFS) was determined. ...
Source: Clinical Colorectal Cancer - Category: Cancer & Oncology Authors: Tags: Mol Clin Oncol Source Type: research
CONCLUSION: The lifetime attributable risk of cancer incidence and mortality due to radiation exposure is not trivial. Therefore efforts should be made to reduce patient doses while maintaining image quality. PMID: 32871427 [PubMed - indexed for MEDLINE]
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Tags: Clin Imaging Source Type: research
Authors: Chen P, Wang H, Li M, Yang L, Mou F, Singh B, He JY, Zhang W Abstract 6,12-Diphenyl-3,9-diazatetraasterane-1, 5, 7, 11-tetracarboxylate (DDTC) has been synthesized by the photodimerization of 4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate. The potential of theercvantitumor activity and mechanism were investigated in vitro using MTT assay in human lung cancer cell line A549, ovarian cancer cell lines SKOV3 and A2780, breast cancer cell line MCF-7, gastric cancer cell line BGC-823, colon cancer cell line HT29, prostate cancer cell line DU145, and liver cancer cell line SMMC7721. The results show that DDTC ca...
Source: Disease Markers - Category: Laboratory Medicine Tags: Dis Markers Source Type: research
Corrigendum to "Mucinous Histology, BRCA1/2 Mutations, and Elevated Tumor Mutational Burden in Colorectal Cancer". J Oncol. 2020;2020:6725209 Authors: Harpaz N, Gatt YE, Granit RZ, Fruchtman H, Hubert A, Grinshpun A Abstract [This corrects the article DOI: 10.1155/2020/6421205.]. PMID: 32963530 [PubMed]
Source: Journal of Oncology - Category: Cancer & Oncology Tags: J Oncol Source Type: research
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