Elevated Testosterone Level and Urine Scent Marking in Male 5xFAD Alzheimer Model Mice.

CONCLUSION: We suggest that overexpression of A®PP which mostly is used to mimic AD in model mice also affects male sexual behavior as assessed by the urine scent marking (USM) test. The elevated testosterone levels additionally might have an impact on central nervous system androgen receptors and also have to be considered when assessing learning and memory capabilities.
PMID: 32065104 [PubMed - as supplied by publisher]

Source: Current Alzheimer Research - February 15, 2020 Category: Neurology Authors: Gadomsky L, Santos Guilherme MD, Winkler J, der Kooij MV, Hartmann T, Grimm M, Endres K Tags: Curr Alzheimer Res Source Type: research