Docking related survey on the Heterocyclic compounds based Glucosamine-6-Phosphate Synthase inhibitors and their antimicrobial potential.

Docking related survey on the Heterocyclic compounds based Glucosamine-6-Phosphate Synthase inhibitors and their antimicrobial potential. Curr Pharm Des. 2020 Feb 16;: Authors: Lather A, Sharma S, Khatkar S, Khatkar A Abstract The synthetic heterocyclic compounds have their importance due to their wide applications in various field of science. The heterocyclic compounds have been reported for their anticancer, antitubercular, insecticides, analeptics, analgesic, anti-bacterial, anti-viral, anti-fungal, and weedicidal activity. Researchers have tried various newer targets for search of better antimicrobials acting via novel mechanisms. Glucosamine-6-Phosphate synthase is an enzyme present in microbial cells. The inactivation of G-6-P synthase may serve as a novel approach to find better antimicrobial. The increasing demands development of newer and effective antimicrobial drugs has reported for the search of newer techniques for the generation of new drugs. Hence, the molecular docking technique shall be explored to find or investigate the newer target to find the novel compounds which can be an active antimicrobial compound. The present review has focused on the reported heterocyclic compounds which have been evaluated for their antimicrobial potential using G-6-P synthase as target. The results of in silico methods and in vitro methods have been compared and critically discussed. PMID: 32065087 [PubMed - as supplied by publi...
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research