The PI3K/AKT/mTOR signaling pathway in osteoarthritis: a narrative review

Osteoarthritis (OA) is a complicated degenerative disease that affects whole joint tissue. Currently, apart from surgical approaches to treat late stage OA, effective treatments to reverse OA are not available. Thus, the mechanisms leading to OA, and more effective approaches to treat OA should be investigated. According to available evidence, the PI3K/AKT/mTOR signaling pathway is essential for normal metabolism of joint tissues, but is also involved in development of OA. To provide a wide viewpoint to roles of PI3K/AKT/mTOR signaling pathway in osteoarthritis, a comprehensive literature search was performed using PubMed terms ‘PI3K OR AKT OR mTOR’ and ‘osteoarthritis’.
Source: Osteoarthritis and Cartilage - Category: Rheumatology Authors: Tags: Review Source Type: research