Amlodipine Better BP Drug for Lower Long-Term Risk for Gout

TUESDAY, Feb. 18, 2020 -- The antihypertensive medication amlodipine is associated with a lower risk for gout compared with other antihypertensive agents, according to a study published online Jan. 20 in the Journal of Hypertension. Stephen P....
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news

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Conclusion: Amlodipine lowered long-term gout risk compared with lisinopril or chlorthalidone. This finding may be useful in cases where gout risk is a principal concern among patients being treated for hypertension. This trial is registered at clinicaltrials.gov, number: NCT00000542.
Source: Journal of Hypertension - Category: Cardiology Tags: ORIGINAL PAPERS: Treatment Source Type: research
AbstractHyperuricemia and risk of gout are commonly seen in patients with type 2 diabetes. It has also been reported that chronically elevated circulating uric acid concentrations are associated with an increased risk of hypertension, cardiovascular disease and chronic kidney disease (CKD), all of which are known diabetes associated complications.
Source: Journal of Diabetes Investigation - Category: Endocrinology Authors: Tags: COMMENTARY Source Type: research
Over the course of three days, intense pain, redness and swelling of the left fifth toe wrought great havoc to a 67-year-old man [Figure 1]. There was no antecedent trauma, insect bite, nor change in medication. He denied fever, chills or walking barefoot. He had known hypertension and vitamin D deficiency. As a child, he was diagnosed with psoriasis; skin lesions intermittently recurred into adulthood. Both his parents had gout and a grandfather had psoriasis.
Source: The American Journal of Medicine - Category: General Medicine Authors: Tags: DIAGNOSTIC DILEMMA Source Type: research
Abstract The association between increased serum urate and hypertension has been a subject of intense controversy. Extracellular uric acid drives uric acid deposition in gout, kidney stones, and possibly vascular calcification. Mendelian randomization studies, however, indicate that serum urate is likely not the causal factor in hypertension although it does increase the risk for sudden cardiac death and diabetic vascular disease. Nevertheless, experimental evidence strongly suggests that an increase in intracellular urate is a key factor in the pathogenesis of primary hypertension. Pilot clinical trials show bene...
Source: American Journal of Hypertension - Category: Cardiology Authors: Tags: Am J Hypertens Source Type: research
CONCLUSIONS: Use of advanced treatment modalities including NPWT, epidermal grafting, and ORC/collagen/silver-ORC dressings contributed to wound healing in these patients with complex and/or chronic wounds. PMID: 32155120 [PubMed - as supplied by publisher]
Source: Wounds - Category: General Medicine Tags: Wounds Source Type: research
CONCLUSIONS: In the German National Cohort, self-reported cardiovascular and metabolic diseases diagnosed by a physician are assessed from all participants, therefore representing a data source for future cardio-metabolic research in this cohort. PMID: 32157352 [PubMed - as supplied by publisher]
Source: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz - Category: International Medicine & Public Health Authors: Tags: Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz Source Type: research
ConclusionsThe main factors that may influence the formation of tophi are disease duration and eGFR.Key Points•Lower eGFR and longer course duration are independent risk factors of tophi formation in gout patients.•The incidence of ultrasound manifestations including double contour sign (DCS) and erosion in patients with tophi were higher than those without tophi.
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
AbstractAnkylosing spondylitis (AS) and gout are common inflammatory arthropathies. It had been claimed previously that the two conditions rarely coexist. The aim of this study was to compare the prevalence of gout in a population of AS patients to its prevalence in the general population. To conduct this population-based case –control study, data of adult patients with a physician diagnosis of AS were retrieved from the database of the largest health-care provider organization in Israel, Clalit Health Services. For each patient with AS, five age- and sex-matched subjects without AS were randomly selected from the sa...
Source: Rheumatology International - Category: Rheumatology Source Type: research
Purpose of review To review advances in the understanding of potentially causal relationships between gout, hyperuricemia and comorbidities. Recent findings Observational studies reveal 4–5 comorbidity clusters in gout patients. There tend to be gout alone, gout with chronic kidney disease and gout with other metabolic comorbidities. However, heterogeneous study populations and confounding make inference difficult for causal relationships. Mendelian randomization leverages genetic information as an instrumental variable to indicate putatively causal relationships between traits of epidemiological interest. Thus ...
Source: Current Opinion in Rheumatology - Category: Rheumatology Tags: EPIDEMIOLOGY AND HEALTH-RELATED SERVICES: Edited by Kenneth G. Saag Source Type: research
(Beth Israel Deaconess Medical Center) A new study led by physician-researchers at Beth Israel Deaconess Medical Center (BIDMC) reports that the antihypertensive drug amlodipine lowered long-term gout risk compared to two other drugs commonly prescribed to lower blood pressure. The findings are published in the Journal of Hypertension.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
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