High Cutaneous Melanoma Burden Found Due to UV Radiation

TUESDAY, Feb. 18, 2020 -- In the United States, the proportion of cases of cutaneous melanoma and age-standardized incidence rates attributable to ultraviolet (UV) radiation vary across states, but the burden is considerable in all states, according...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news

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Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencing ; OtherOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Genome binding/occupancy profiling by high throughput sequencing Other Homo sapiens Source Type: research
Contributors : Rosela Golloshi ; Rebeca San Martin ; Priyojit Das ; Delaney Thurston ; Trevor F Freeman ; Thomas I Raines ; Rachel P McCordSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe investigate the effect of constricted migration (using transwell assays with 5- μm or 12-μm in diamter) on the organization of the 3D genome in melanoma cells.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Contributors : Rosela Golloshi ; Rebeca San Martin ; Priyojit Das ; Delaney Thurston ; Trevor F Freeman ; Thomas I Raines ; Rachel P McCordSeries Type : OtherOrganism : Homo sapiensWe investigate the effect of constricted migration (using transwell assays with 5- μm or 12-μm in diamter) on the organization of the 3D genome in melanoma cells.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research
Contributors : Rosela Golloshi ; Rebeca San Martin ; Priyojit Das ; Delaney Thurston ; Trevor F Freeman ; Thomas I Raines ; Rachel P McCordSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensWe investigate the effect of constricted migration (using transwell assays with 5- μm or 12-μm in diamter) on the organization of the 3D genome in melanoma cells.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
Contributor : Johannes TextorSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCancer vaccines utilizing naturally circulating dendritic cell (DC) subsets, such as plasmacutoid DCs (pDCs) and type 2 convential DCs (cDC2s), have demonstrated their potential as a therapy. For melanoma in recent clinical trials. These DC vaccines aim to. human. DC subsets on the. T cell transcriptional program, which. forms the. molecular. basis. of an. antitumor. T cell response, is. poorly understood. In. this study, we investigated the eraly gene expressionsignature of CD8+ T. cells following. stimulati...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Publication date: Available online 29 March 2020Source: Life SciencesAuthor(s): Wancong Zhang, Hanxing Zhao, Jiasheng Chen, Xiaoping Zhong, Weiping Zeng, Zhonglei Li, Jianda Zhou, Zhihao He, Shijie Tang
Source: Life Sciences - Category: Biology Source Type: research
CONCLUSIONS: This study confirms the need for a full body skin examination and a prolonged surveillance in patients affected by cM, as MPMs were detected in up to 10% of total cases in our series and synchronous lesions in 1/5. Moreover, it reflects the great variability of cM high- susceptibility genes mutational status within the Italian territory. Patients carrying c.952G>A (p.Glu318Lys) MITF mutation have a higher risk to develop a nodular cM. PMID: 32221274 [PubMed - as supplied by publisher]
Source: Giornale Italiano di Dermatologia e Venereologia - Category: Dermatology Tags: G Ital Dermatol Venereol Source Type: research
In conclusion, sitagliptin may have a potential inhibitory effect on GC by AMPK/YAP/melanoma‐associated antigen‐A3 pathway.
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
We describe here the presence of mechanically activated currents in melanoma cells that are dependent on TMEM87a, which we have renamed Elkin1. Heterologous expression of this protein in PIEZO1-deficient cells, that exhibit no baseline mechanosensitivity, is sufficient to reconstitute mechanically activated currents. Melanoma cells lacking functional Elkin1 exhibit defective mechanoelectrical transduction, decreased motility and increased dissociation from organotypic spheroids. By analysing cell adhesion properties, we demonstrate that Elkin1 deletion is associated with increased cell-substrate adhesion and decreased homo...
Source: eLife - Category: Biomedical Science Tags: Cancer Biology Cell Biology Source Type: research
In conclusion, we developed a lecithin-based dermal delivery method for ceramide using zebrafish larvae with implications for human clinical use.
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
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