Biomechanical comparison of four tibial fixation techniques for meniscal root sutures in posterior medial meniscus root repair: A porcine study

This study investigated the fixation stability of four different tibial fixations for the meniscal root sutures. Twenty-four porcine tibiae with intact medial meniscus roots were randomly assigned into four groups: transosseous suture, washer, suture anchor or screw with washer. Each sample underwent cyclic loading followed by a load-to-failure test. The maximum average load and displacement at failure for each of the repair groups were as follows: transosseous suture, 232.8 ​N and 12.16 ​mm; washer, 189.9 ​N and 21.5 ​mm; suture anchor, 140.6 ​N and 13.8 ​mm and screw with washer, 167.9 ​N and 18.9 ​mm. The maximum stiffness values for each of the repair groups were as follows: transosseous suture, 19.5 ​± ​0.7 ​N/mm; washer, 21.5 ​± ​1.4 ​N/mm; suture anchor, 13.8 ​± ​0.7 ​N/mm and screw with washer, 18.9 ​± ​3.9 ​N/mm. The mean elongation across the repairs for each of the repair groups after 1000 loading cycles was: transosseous suture, 3.74 ​± ​0.28 ​mm; washer, 3.04 ​± ​0.13 ​mm; suture anchor, 2.25 ​± ​0.33 ​mm and screw with washer, 2.43 ​± ​0.19 ​mm. The mean elongation was significantly less with the suture anchor than with the other techniques (p ​
Source: Journal of Orthopaedic Translation - Category: Orthopaedics Source Type: research

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Daniel J. IkensonSome people talk about trade as though it were an end in itself. It ’s not. Trade is a means to an end.We trade so that we can specialize. We specialize so that we can produce more. We produce more so that we can consume and save more. That is how we create wealth and raise living standards. Just like electricity or machinery or expertise, trade is a tool we use to leverage our physical, mental, and creative abilities to obtain more efficiently more of the things we need and want. When we remove barriers to trade, we create greater scope for specialization, which means we can produce more v...
Source: Cato-at-liberty - Category: American Health Authors: Source Type: blogs
Purpose of review Macrophages play an important role in regulating homeostasis, kidney injury, repair, and tissue fibrogenesis. The present review will discuss recent advances that explore the novel subsets and functions of macrophage in the pathogenesis of kidney damage and hypertension. Recent findings Macrophages differentiate into a variety of subsets in microenvironment-dependent manner. Although the M1/M2 nomenclature is still applied in considering the pro-inflammatory versus anti-inflammatory effects of macrophages in kidney injury, novel, and accurate macrophage phenotypes are defined by flow cytometric marke...
Source: Current Opinion in Nephrology and Hypertension - Category: Urology & Nephrology Tags: RENAL IMMUNOLOGY AND PATHOLOGY: Edited by Agnes B. Fogo Source Type: research
Purpose of review The recent years have been marked by the publication of several articles highlighting the pathophysiological role of glomerular parietal epithelial cells (PEC) and refining their phenotypic heterogeneity. Recent findings The present review synthetizes recent findings on (i) the potential regenerative role of PEC in glomerular diseases, and (ii) the mechanisms and signaling of leading to PEC pathogenic involvement in crescentic glomerulonephritis (CGN) and focal segmental glomerulosclerosis (FSGS). Summary The debate is still open regarding the podocyte regenerative properties of PEC in glomerular ...
Source: Current Opinion in Nephrology and Hypertension - Category: Urology & Nephrology Tags: RENAL IMMUNOLOGY AND PATHOLOGY: Edited by Agnes B. Fogo Source Type: research
Purpose of review Despite improvements in acute kidney injury (AKI) detection, therapeutic options to halt the progression of AKI to chronic kidney disease (CKD) remain limited. In this review, we focus on recent discoveries related to the pathophysiology of the AKI to CKD continuum, particularly involving the renal tubular epithelial cells, and also discuss related ongoing clinical trials. While our focus is on injured renal tubular epithelial cells as initiators of the cascade of events resulting in paracrine effects on other cells of the kidney, the summation of maladaptive responses from various kidney cell types ult...
Source: Current Opinion in Nephrology and Hypertension - Category: Urology & Nephrology Tags: RENAL IMMUNOLOGY AND PATHOLOGY: Edited by Agnes B. Fogo Source Type: research
Purpose of review The sensitivity of semen analysis for detection of infertility remains low. Many factors not measured in traditional semen analysis may contribute to male factor infertility. DNA fragmentation, oxidative stress, and sperm aneuploidy are three factors that may contribute further information to the evaluation when semen analysis is inconclusive. Recent findings DNA fragmentation measures the destruction of and failure to repair damage to DNA. Increased DNA fragmentation has been used as a marker for oxidative stress as well as toxic exposure. The oxidative stress adduct measures DNA aberrations, which ...
Source: Current Opinion in Urology - Category: Urology & Nephrology Tags: GENDER MEDICINE, INFERTILITY AND ERECTILE FUNCTION: Edited by Ryan Flannigan and Ranjith Ramasamy Source Type: research
Publication date: April 2020Source: Journal of the American College of Radiology, Volume 17, Issue 4Author(s): Celena Romero, Frank J. Rybicki
Source: Journal of the American College of Radiology - Category: Radiology Source Type: research
CONCLUSIONS AND PRACTICAL IMPLICATIONS: Posterior multiunit ZC restorations are considered a predictable treatment in the medium term, although they are slightly more susceptible to chipping of the veneering ceramic than MC restorations. PMID: 32222175 [PubMed - in process]
Source: Journal of the American Dental Association - Category: Dentistry Tags: J Am Dent Assoc Source Type: research
Cellular senescence is one of the contributing causes of aging, in the sense that senescent cells accumulate in old tissues. Even when only a tiny fraction of all cells are senescent, their signaling causes chronic inflammation and disruption of tissue function. Senescence is, however, a helpful program when these cells exist only temporarily and are promptly destroyed. The signaling that is so harmful when maintained over the long term aids in wound healing and suppression of cancer when present for a short time only. Since the comparatively recent acceptance of senescent cells as an important cause of aging, the research...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Researchers here consider a very conservative set of interventions known to modestly slow the progression of aging in laboratory species, largely by altering metabolism to upregulate beneficial cellular stress responses. The researchers look through the lens of lung aging, specifically, reviewing the evidence for these therapies to slow the deterioration in lung function and onset of lung disease in older individuals, or to be the basis for treating established lung disease. To date, the most reliable, best-researched way to extend life span is through the practice of calorie restriction (CR), which involves reduc...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Contributors : Hanseul Yang ; Rene Adam ; Elaine FuchsSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusTissue homeostasis and regeneration rely upon resident stem cells (SCs), whose behavior is regulated through niche-dependent crosstalk. The mechanisms underlying SC maintenance are still unfolding. Here, using hair follicles (HFs) as model and spatiotemporal gene ablation in mice, we uncover transcription factors (TFs) NFIB and NFIX as guardians of the process. Complete NFI ablation causes SC depletion and hair loss which resembles irreversible alopecia in humans, who in...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Mus musculus Source Type: research
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