New Hampshire, Vermont On List Of States With Highest Risk Of Melanoma Linked To UV Rays

(CNN) — States with the highest rates of melanoma cases linked to ultraviolet radiation are spread across the United States on the East and West coasts, in Hawaii and in landlocked states, according to a study published Monday in the International Journal of Cancer. Melanoma is one of the most rapidly increasing cancers in the United States, jumping 2% per year between 2005 and 2015 in both men and women, the study found, with an estimated 151,000 cases a year by 2030 up from just over 96,000 in 2019, if current trends continue. It is also the deadliest type of all skin cancers and linked to UV radiation exposure in nearly 95% of all cases in the United States. It’s potentially preventable, because diagnoses are associated with “excessive sun exposure and indoor tanning,” the authors said. “High indoor tanning prevalence among teen girls in the late 1990s is likely a contributing factor,” said lead study author Dr. Farhad Islami, a cancer epidemiologist with the American Cancer Society, referring to the rising number of melanoma diagnoses. NOW ONLINE Read the new article by @AmericanCancer &@HarvardChanSPH authors, Farhad Islami et al. | Cutaneous melanomas attributable to ultraviolet radiation exposure by state | #Melanoma #incidence #UnitedStates #epitwitter — International Journal of Cancer (@IntJCanc) February 17, 2020 The strength of ultraviolet radiation is generally mea...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health CNN New Hampshire News Skin Cancer Vermont News Source Type: news

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Contributor : Johannes TextorSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCancer vaccines utilizing naturally circulating dendritic cell (DC) subsets, such as plasmacutoid DCs (pDCs) and type 2 convential DCs (cDC2s), have demonstrated their potential as a therapy. For melanoma in recent clinical trials. These DC vaccines aim to. human. DC subsets on the. T cell transcriptional program, which. forms the. molecular. basis. of an. antitumor. T cell response, is. poorly understood. In. this study, we investigated the eraly gene expressionsignature of CD8+ T. cells following. stimulati...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
CONCLUSIONS: This study confirms the need for a full body skin examination and a prolonged surveillance in patients affected by cM, as MPMs were detected in up to 10% of total cases in our series and synchronous lesions in 1/5. Moreover, it reflects the great variability of cM high- susceptibility genes mutational status within the Italian territory. Patients carrying c.952G>A (p.Glu318Lys) MITF mutation have a higher risk to develop a nodular cM. PMID: 32221274 [PubMed - as supplied by publisher]
Source: Giornale Italiano di Dermatologia e Venereologia - Category: Dermatology Tags: G Ital Dermatol Venereol Source Type: research
In conclusion, sitagliptin may have a potential inhibitory effect on GC by AMPK/YAP/melanoma‐associated antigen‐A3 pathway.
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
We describe here the presence of mechanically activated currents in melanoma cells that are dependent on TMEM87a, which we have renamed Elkin1. Heterologous expression of this protein in PIEZO1-deficient cells, that exhibit no baseline mechanosensitivity, is sufficient to reconstitute mechanically activated currents. Melanoma cells lacking functional Elkin1 exhibit defective mechanoelectrical transduction, decreased motility and increased dissociation from organotypic spheroids. By analysing cell adhesion properties, we demonstrate that Elkin1 deletion is associated with increased cell-substrate adhesion and decreased homo...
Source: eLife - Category: Biomedical Science Tags: Cancer Biology Cell Biology Source Type: research
Source: BMJ Comments - Category: General Medicine Source Type: forums
BRAFTOVI is a drug which is to be used with another drug, binimetinib, to treat a type of skin cancer called melanoma.
Source: FDA Center for Drug Evaluation and Research - What's New - Category: Drugs & Pharmacology Authors: Source Type: news
ConclusionsWe find sufficient cause to suggest that the predictive clinical value of TMB should not be overstated or oversimplified. While it is readily quantified, TMB is at best a limited surrogate biomarker of immunotherapy response. The data do not support isolated use of TMB in renal cell carcinoma.
Source: Genome Medicine - Category: Genetics & Stem Cells Source Type: research
AbstractThe globally increasing incidence of cancer, including melanoma, requires novel therapeutic strategies. Development of successful novel drugs is based on clear identification of the target mechanisms responsible for the disease progression. The specific cancer microenvironment represents a critically important aspect of cancer biology, which cannot be properly studied in simplistic cell culture conditions. Among other traditional options, the study of melanoma cell growth on the chicken chorioallantoic membrane offers several significant advantages. This model offers increased complexity compared to usual in silico...
Source: Histochemistry and Cell Biology - Category: Biomedical Science Source Type: research
Girolomoni Caterina Foti Occupational exposure to ultraviolet radiation is one of the main risk factors for non-melanoma skin cancer (NMSC) development. The most common variants of NMSC are basal cell carcinomas, squamous cell carcinomas, and actinic keratosis (AK). The latter is nowadays considered by most authors as an early squamous cell carcinoma rather than a precancerous lesion. Outdoor workers have a higher risk of developing NMSC because they spend most of the working day outside. The aim of this descriptive study was to assess the prevalence of skin lesions, especially AK, in a professional category of indi...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Authors: Cabanillas M, Dadu R, Iyer PC, Wanland KB, Busaidy N, Ying AK, Gule-Monroe M, Wang JR, Zafereo M, Hofmann MC Abstract The BRAFV600E mutation is the most common driver mutation in papillary thyroid cancer (PTC) and anaplastic thyroid cancer (ATC). This mutation is considered actionable and, for BRAFV600E-mutated ATC, a BRAF inhibitor (dabrafenib) in combination with a MEK inhibitor (trametinib) is FDA approved. BRAF inhibitors have also shown efficacy in BRAFV600E-mutated PTC. However, as with all targeted therapies, resistance to these drugs eventually occurs. It is essential that we understand the mechani...
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
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