Selepressin for Patients With Septic Shock

To the Editor Compared with placebo, the nonadrenergic vasopressor angiotensin II was shown to increase mean arterial pressure after 3 hours in patients with vasodilatory shock in the Angiotensin II for the Treatment of High-Output Shock (ATHOS-3) trial (primary end point). In addition, angiotensin II also reached the secondary goal of a greater reduction in the cardiovascular Sequential Organ Failure Assessment (SOFA) score after 48 hours vs placebo. As a consequence, research with angiotensin II continued and it was approved by the US Food and Drug Administration.
Source: JAMA - Category: General Medicine Source Type: research

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This study demonstrates the safety and efficacy profile of ATO/ATRA first-line therapy for patients with APL and high-risk features for early death.
Source: Annals of Hematology - Category: Hematology Source Type: research
Source: Critical Care - Category: Intensive Care Authors: Tags: Research Letter Source Type: research
This study was performed to investigate the association between serum total carbon dioxide (TCO2) concentration and 28-day mortality in patients with sepsis.
Source: The American Journal of Emergency Medicine - Category: Emergency Medicine Authors: Source Type: research
Sepsis is a significant cause of mortality, and improving survival has gained a lot of attention over the last 2 decades as a measure for quality improvement. Mortality rates from sepsis as high as 49.7% were the stimulus for Rivers et al to develop early goal-directed therapy in 2001, resulting in significantly lower mortality rates (30.5%). In 2002, the Surviving Sepsis Campaign, an international effort led by intensivists, began promoting early recognition and treatment of sepsis. This campaign ultimately led to the adoption of Early Management Bundle for Severe Sepsis/Septic Shock (SEP-1) by the US Centers for Medicare...
Source: JAMA Internal Medicine - Category: Internal Medicine Source Type: research
Publication date: Available online 2 April 2020Source: Urology Case ReportsAuthor(s): Wubin Tan, Tieqiu Li, Ke Yang, Zheng Mao, Jiahui Li
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
CONCLUSIONS: Thiol/disulphide homeostasis is impaired in patients with sepsis and septic shock. Understanding the role of thiol/disulphide homeostasis in sepsis and septic shock may provide different therapuetic intervention strategies for patients. PMID: 32233178 [PubMed - as supplied by publisher]
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
Publication date: Available online 1 April 2020Source: International Journal of Surgery Case ReportsAuthor(s): Victoria Lu, Harsh Kanhere
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
This study aimed to evaluate the association between hemodynamic and skin perfusion parameters and enteral nutrition therapy (NT) outcomes in septic shock patients.
Source: Clinical Nutrition - Category: Nutrition Authors: Tags: Original article Source Type: research
Conclusion: We provided “cell-block” method, which collects cell components from large amount of CSF for cytology and immunohistochemical analysis. “Cell-block” cytology can be an alternative diagnostic method in diagnosis of PCNSL.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
A psoas abscess is a rare but potentially devastating condition that is associated with risks of neurological deficits, septic shock, and even death. The current first-line treatment is percutaneous catheter drainage (PCD) under imaging guidance, combined with broad-spectrum antibiotics. Surgical drainage should be considered if PCD fails or is impossible. Although many studies on PCD and open surgical drainage have appeared, the outcomes of laparoscopic drainage have rarely been reported. Thus, we laparoscopically drained the psoas abscesses of 6 patients; drainage was complete and we encountered no recurrence or complic...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
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