Lesional inflammatory profile in Hidradenitis Suppurativa is not solely driven by IL-1
Immune dysregulation is strongly implicated in the pathogenesis of hidradenitis suppurativa (HS).(Vossen et al., 2018) This is demonstrated by the presence of inflammation in both lesional and perilesional HS skin (Kelly et al., 2015; Van der Zee et al., 2012; Witte-H ändel et al., 2019). However, our current understanding of HS pathophysiology, with follicular occlusion and rupture as the primary events, is under scrutiny. A complex immune driven pathogenesis, initiated by an initial aberrant immune response to a possibly dysbiotic cutaneous microbiome, is susp ected, with follicular occlusion occurring as a secondary phenomenon.(Frew, 2019) It is presumed that commensal bacterial products like lipopolysaccharide, peptidoglycan, and bacterial DNA and RNA as well as complex keratin filaments released after follicular rupture promote the simultaneous activat ion of multiple auto-inflammatory pathways such as membrane and cytosolic innate receptors, complement and the NLRP inflammasome.
Publication date: Available online 29 March 2020Source: Actas Dermo-Sifiliográficas (English Edition)Author(s): M.J. Sánchez-Pujol, P. Álvarez-Chinchilla, A. Docampo-Simón, J.C. Pascual Ramírez
Abstract White fibrous papulosis of the neck is a rare entity, with fewer than 50 cases described. It is a benign pathology whose main interest lies in its broad differential diagnosis, especially with pseudoxanthoma elasticum. The authors report the case of a 77-year-old woman with multiple yellow-white monomorphic papules on the posterior cervical region, with years of evolution. Cutaneous biopsy revealed a nodular area in the superficial and middle reticular dermis, with slight thickening of the collagen fibers and focally enlarged elastic fibers, aspects highlighted in the Verhoeff staining that additionally showed abs...
Condition: Hidradenitis Suppurativa Interventions: Procedure: Excision of HS followed by NPWTi; Procedure: Excision of HS followed by NPWT Sponsors: Royal Free Hospital NHS Foundation Trust; KCI Europe Holding B.V. Recruiting
Skin is the largest peripheral endocrine organ and functions as a hormone target and endocrine gland. A cutaneous hypothalamus-pituitary-adrenal (HPA)-like axis enables the skin to respond to stress and regulates its steroidogenic activity. The pilosebaceous unit is a site for production and metabolism of a number of steroid hormones, including stress and sex hormones. This is an overview of the important role that the cutaneous HPA-like-axis plays in the pathogenesis and treatment of inflammatory pilosebaceous disorders, including acne, rosacea, seborrheic dermatitis, and hidradenitis suppurativa.
We present a 26-year-old man with a history of pemphigus foliaceus (PF) who developed large draining nodules with scarring and sinus tracts, compatible with follicular occlusion triad, preferentially at areas previously affected by PF thirteen months after treatment with rituximab. To the authors' knowledge there are no reported cases of follicular occlusion triad or HS manifesting as an isotopic response. However, one member of the triad, HS, has been reported to occur infrequently following the use of biologic agents...
CONCLUSIONS: The description of discharge symptoms experienced by many patients is similar to the description of symptoms of an umbilical pilonidal sinus (UPS). This is a condition with a morphology reminiscent to that of HS because it is defined by sinus tract formation triggered by hair penetrating the umbilical skin. UPS could be an explanation for umbilical HS symptom. PMID: 32206815 [PubMed - in process]
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder. Previous studies have yielded divergent results on the prevalence of depression and anxiety in HS patients.
The ICAReB platform of Institut Pasteur provides access to human bio-resources for academic and private research teams worldwide, essentially in the fields of infection, immunity and neurosciences. More than 134,000 human quality controlled, duly annotated samples (mainly whole-blood derived products, but also stool, urine, saliva, swabs ….), from both healthy and diseased cohorts with open, regulated access, are available upon request. Both clinical investigation and biobanking activities are certified following ISO 9001:2015 and NF S96-900:2011 standards, respectively. ICAReB is a member of PIBnet (Pasteur Interna...
The authors would like to correct the error in publication which is mentioned below.
Publication date: Available online 20 March 2020Source: Actas Dermo-Sifiliográficas (English Edition)Author(s): J.M. Rueda Carnero, D. Nieto Rodríguez, R. de Lucas Laguna, M. Feito Rodríguez