Nuclear receptors in abdominal aortic aneurysms
Abdominal aortic aneurysms (AAA) pose a considerable health burden and at present are only managed surgically since there is no proven pharmacotherapy that will retard their expansion or reduce the incidence of fatal rupture. This pathology shares several pathophysiological mechanisms with atherosclerosis, such as macrophage infiltration, inflammation, and degradation of extracellular matrix. Therefore, therapeutic targets proven effective in the treatment of atherosclerosis could also be considered for treatment of AAA.
Source: Atherosclerosis - Category: Cardiology Authors: Jaap G. Neels, R éda Hassen-Khodja, Giulia Chinetti Tags: Review article Source Type: research