Class A CpG oligodeoxynucleotide inhibits IFN ‐γ‐induced signaling and apoptosis in lung cancer

ConclusionsThis study suggests that ODNs containing six or more consecutive guanosines may inhibit the binding of IFN ‐γ to IFN‐γ receptor. However, it does not directly show that ODNs containing six or more consecutive guanosines competitively inhibit the IFN‐γ receptor, and further studies are warranted to confirm this finding.Key pointsSignificant findings of the study: Oligodeoxynucleotides with a contiguous sequence of six or more guanosines may competitively inhibit the IFN ‐γ receptor and abolish the action of IFN‐γ. This may suppress IFN‐γ‐induced apoptosis and indoleamine‐2,3‐dioxygenase‐1 expression in human lung cancer cells.What this study adds: A ‐CpG and poly‐G ODN may overcome tolerance if the cause of ICI tolerance is high IDO expression. However, IFN‐γ also has the effect of suppressing apoptosis of cancer cells, and it is necessary to identify the cause of resistance.

Source: Thoracic Cancer - February 18, 2020 Category: Cancer & Oncology Authors: Shuhei Teranishi, Nobuaki Kobayashi, Seigo Katakura, Chisato Kamimaki, Sousuke Kubo, Yuji Shibata, Masaki Yamamoto, Makoto Kudo, Hongmei Piao, Takeshi Kaneko Tags: Original Article Source Type: research