Determination of minimum bactericidal concentration, in single or combination drugs, against Mycobacterium tuberculosis

Future Microbiology, Ahead of Print.
Source: Future Microbiology - Category: Microbiology Authors: Source Type: research

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Publication date: Available online 2 April 2020Source: The Journal of Foot and Ankle SurgeryAuthor(s): Changgui Zhang, Yangjing Lin, Chengchang Zhang, Jin Cao, Liu Yang, Xiaojun Duan
Source: The Journal of Foot and Ankle Surgery - Category: Orthopaedics Source Type: research
Authors: Tezuka T, Inayama M, Suzue R, Miyamoto K, Haku T Abstract Pulmonary tuberculosis is a common disease that may result in hemoptysis. Fetal hemoptysis is known to be related to the rupture of a pulmonary aneurysm formed in the cavity wall. We herein report a case of non-cavity pulmonary tuberculosis that developed with massive hemoptysis following bronchial artery aneurysm. Bronchial artery embolization was performed, and autofluorescence imaging bronchoscopy was conducted one month after the anti-tuberculosis treatment. Bright-green color was observed in the ulcerative lesion with a white coat, correspondin...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Discussions (FGDs) with DR-TB patients. The desk review of 38 reports identified as the main challenges to address DR-TB financial and/or management issues and adverse events of the medicines. The most common recommendations related to treatment outcome focussed on general programme management, treatment regimen composition, clinical management and social support for the patients. In all the five countries the NTPs still have a vertical structure. Some integration into the primary health care system (PHC) already exists but further involvement of PHC facilities is feasible and recommended. Interviews with stakeholders indi...
Source: Monaldi Archives for Chest Disease - Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research
Authors: Schlipköter U, Flahault A Abstract The past two centuries have seen enormous achievements in control of infectious diseases, previously the leading cause of death, in large measure due to sanitation and food safety, vaccines, antibiotics and improved nutrition. This has led people to put their faith in the notion that medical science would succeed in overcoming the remaining obstacles. Vaccination has eradicated smallpox, nearly eradicated poliomyelitis and greatly reduced many other highly dangerous infections such as diphtheria, tetanus and measles. New diseases such as HIV and new forms of influenz...
Source: Public Health Reviews - Category: International Medicine & Public Health Tags: Public Health Rev Source Type: research
Mycobacterium tuberculosis produces glycogen (also known as α -glucan) to help evade human immunity. This pathogen uses the GlgE pathway to generate glycogen rather than the more well known glycogen synthase GlgA pathway, which is absent in this bacterium. Thus, the building block for this glucose polymer is α -maltose-1-phosphate rather than an NDP-glucose donor. One of the routes to α -maltose-1-phosphate is now known to involve the GlgA homologue GlgM, which uses ADP-glucose as a donor and α -glucose-1-phosphate as an acceptor. To help compare GlgA (a GT5 family member) with GlgM enzymes (GT4 fam...
Source: Acta Crystallographica Section F - Category: Biochemistry Authors: Tags: GlgM α -maltose-1-phosphate synthase glycosyltransferase glycogen -glucan research communications Source Type: research
BCG, or Bacillus Calmette-Gu érin, is a vaccine for tuberculosis and is administered at birth in countries that have historically suffered from the disease, such as India. Many rich nations, such as the US, Italy and Holland, have never had a universal BCG vaccination policy.
Source: The Economic Times - Category: Consumer Health News Source Type: news
There is no vaccine against the novel coronavirus, called SARS-CoV-2, that is spreading rapidly around the world. But scientists in several countries are testing a century-old tuberculosis (TB) vaccine to see if it might boost the immune system to reduce respiratory symptoms in people who get new coronavirus infections.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
Purpose of review Pulmonary nontuberculous mycobacterial disease (NTM) remains a significant clinical challenge with suboptimal therapy. This review focuses on recent understandings around the pathogenesis of NTM disease and nonantibiotic therapeutic approaches that are being pursued. Recent findings The absence of animal models that truly replicate human disease remains a major problem for NTM research with most findings coming from tuberculosis or tuberculosis-like studies. Recent research reiterates the known key roles of interferon gamma (IFNγ), tumor necrosis factor, interleukin-12 and granulocyte-macrophag...
Source: Current Opinion in Pulmonary Medicine - Category: Respiratory Medicine Tags: INFECTIOUS DISEASES: Edited by Michael S. Niederman and Alimuddin Zumla Source Type: research
Purpose of review Multiple lines of evidence support a role of the host genetic component in Mycobacterium tuberculosis infection and disease progression. However, genomic studies of tuberculosis susceptibility have been disappointing compared with that of other complex disorders. Recently the field has explored alternative strategies to facilitate locus discovery. Results emanating from these efforts during the last 18 months are addressed in this review. Recent findings There has been a renewed focus on the refinement of phenotypic definitions of infection and disease as well as on age-related, sex-specific and popu...
Source: Current Opinion in Pulmonary Medicine - Category: Respiratory Medicine Tags: GENETICS: Edited by Coline H.M. van Moorsel Source Type: research
Condition:   Latent Tuberculosis Intervention:   Sponsors:   Corporacion para Investigaciones Biologicas;   Universidad Pontificia Bolivariana;   Universidad de Antioquia;   Secretaría de Salud de Medellín;   Secretaría Seccional de Salud y Protección Social de Antioquia;   Hospital Pablo Tobón Uribe Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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