Plasma Myokine Concentrations After Acute Exercise in Non-obese and Obese Sedentary Women

Exercise and physical activity levels influence myokine release from skeletal muscle and contribute to circulating concentrations. Indeed, many myokines, including interleukin (IL)-6, IL-15, secreted protein acidic rich in cysteine (SPARC), and fibroblast growth factor (FGF) 21 are higher in the circulation after an exercise bout. Since these peptides modulate muscle metabolism and can also be targeted toward other tissues to induce adaptations to energy demand, they are of great interest regarding metabolic diseases. Therefore, we set out to compare, in six women with obesity (BMI ≥30 kg/m2) and five healthy women (BMI 22–29.9 kg/m2), the effect of an acute bout of moderate-intensity, continuous cycling exercise (60 min, 60% VO2peak) on the release of myokines (IL-6, IL-8, IL-10, IL-13, IL-15, SPARC, and FGF21) in plasma for a 24-h time course. We found that plasma IL-8 and SPARC levels were reduced in the group of women with obesity, whereas plasma IL-13 concentrations were elevated in comparison to non-obese women both before and after the exercise bout. We also found that plasma FGF21 concentration during the 24 h following the bout of exercise was regulated differently in the non-obese in comparison to obese women. Plasma concentrations of FGF21, IL-6, IL-8, IL-15, and IL-18 were regulated by acute exercise. Our results confirm the results of others concerning exercise regulation of circulating myokines while providing insight into the time course of myokine rel...
Source: Frontiers in Physiology - Category: Physiology Source Type: research

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In this study, we examined the effect of laparoscopic-guided transversus abdominis plane block (LG TAP) for further optimizing multimodal pain control.MethodsThis is a retrospective analysis of a prospectively collected database of 140 consecutive patients undergoing LSG without TAP block (pre-TAP group) compared to 131 patients undergoing LSG with LGTAP (TAP group). All operations were performed laparoscopically utilizing uniform clinical pathways. Baseline characteristics for both groups were comparable. Both groups received standardized anesthesia. Outcomes included time to postoperative ambulation, pain scores, PCA vol...
Source: Surgical Endoscopy - Category: Surgery Source Type: research
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Source: Surgical Endoscopy - Category: Surgery Source Type: research
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Source: Surgical Endoscopy - Category: Surgery Source Type: research
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Source: Health News - - Category: Consumer Health News Source Type: news
Authors: Ventura CG, Roque FL, Sousa IQ, Lobo RD, Luders C Abstract INTRODUCTION: Chronic hemodialysis (HD) patients are considered to be at high risk for infection. Here, we describe the clinical outcomes of chronic HD patients with influenza A (H1N1) infection and the strategies adopted to control an outbreak of influenza A in a dialysis unit. METHODS: Among a total of 62 chronic HD patients, H1N1 infection was identified in 12 (19.4%). Of the 32 staff members, four (12.5%) were found to be infected with the H1N1 virus. Outcomes included symptoms at presentation, comorbidities, occurrence of hypoxemia, hospit...
Source: Jornal Brasileiro de Nefrologia - Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research
Condition:   Non-alcoholic Fatty Liver Disease (NAFLD) Interventions:   Drug: Metabolic Cofactor Supplementation;   Drug: Sorbitol Sponsors:   ScandiBio Therapeutics AB;   Koç University;   Koç University Hospital;   Göteborg University;   Sahlgrenska University Hospital, Sweden;   KTH Royal Institute of Technology;   University of Helsinki;   Helsinki University Central Hospital;   Monitor CRO Recruiting
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Conditions:   Obesity;   Surgery;   Anesthesia Intervention:   Other: no intervention Sponsor:   University of Vermont Medical Center Completed
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Condition:   Obesity-Associated Insulin Resistance Intervention:   Drug: Moxonidine Sponsor:   Italo Biaggioni Not yet recruiting
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Condition:   Obesity, Childhood Intervention:   Sponsor:   Centre Hospitalier Universitaire de la Réunion Not yet recruiting
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Source: Current Opinion in Urology - Category: Urology & Nephrology Tags: GENDER MEDICINE, INFERTILITY AND ERECTILE FUNCTION: Edited by Ryan Flannigan and Ranjith Ramasamy Source Type: research
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