Plasma Myokine Concentrations After Acute Exercise in Non-obese and Obese Sedentary Women

Exercise and physical activity levels influence myokine release from skeletal muscle and contribute to circulating concentrations. Indeed, many myokines, including interleukin (IL)-6, IL-15, secreted protein acidic rich in cysteine (SPARC), and fibroblast growth factor (FGF) 21 are higher in the circulation after an exercise bout. Since these peptides modulate muscle metabolism and can also be targeted toward other tissues to induce adaptations to energy demand, they are of great interest regarding metabolic diseases. Therefore, we set out to compare, in six women with obesity (BMI ≥30 kg/m2) and five healthy women (BMI 22–29.9 kg/m2), the effect of an acute bout of moderate-intensity, continuous cycling exercise (60 min, 60% VO2peak) on the release of myokines (IL-6, IL-8, IL-10, IL-13, IL-15, SPARC, and FGF21) in plasma for a 24-h time course. We found that plasma IL-8 and SPARC levels were reduced in the group of women with obesity, whereas plasma IL-13 concentrations were elevated in comparison to non-obese women both before and after the exercise bout. We also found that plasma FGF21 concentration during the 24 h following the bout of exercise was regulated differently in the non-obese in comparison to obese women. Plasma concentrations of FGF21, IL-6, IL-8, IL-15, and IL-18 were regulated by acute exercise. Our results confirm the results of others concerning exercise regulation of circulating myokines while providing insight into the time course of myokine rel...
Source: Frontiers in Physiology - Category: Physiology Source Type: research

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In this study, we examined the effect of laparoscopic-guided transversus abdominis plane block (LG TAP) for further optimizing multimodal pain control.MethodsThis is a retrospective analysis of a prospectively collected database of 140 consecutive patients undergoing LSG without TAP block (pre-TAP group) compared to 131 patients undergoing LSG with LGTAP (TAP group). All operations were performed laparoscopically utilizing uniform clinical pathways. Baseline characteristics for both groups were comparable. Both groups received standardized anesthesia. Outcomes included time to postoperative ambulation, pain scores, PCA vol...
Source: Surgical Endoscopy - Category: Surgery Source Type: research
ConclusionsThis is the first report of cognitive improvements following VSG and the first direct comparison of cognitive improvements following RYGB and VSG. Short-term improvements in specific domains of cognitive function are observed at the beginning of the active weight loss phase following bariatric surgery that persisted to 3  months. The anatomical distinction between the two surgeries and resulting differential metabolic profiles may be responsible for the improvements in attention observed following RYGB but not following VSG.
Source: Surgical Endoscopy - Category: Surgery Source Type: research
This study aims to assess the referral and practice patterns of PCPs treating patients with obesity. Our goal is to understand treatment barriers in order to implement targeted interventions that enhance quality of care.MethodsA 39-question electronic survey was emailed to PCPs at a single academic institution with community physicians. Questions explored providers ’ demographics, referral patterns, and knowledge of pathophysiologic obesity mechanisms and bariatric surgery qualifications. Frequency and univariate analyses were performed and compared providers’ demographics, positions, and BMIs between referring...
Source: Surgical Endoscopy - Category: Surgery Source Type: research
Women who engage in 90 minutes of mat Pilates weekly saw blood pressure declines of up to six points, and experienced a drop in their percentage of body fat, according to study results published Wednesday in American Jou
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news
Authors: Ventura CG, Roque FL, Sousa IQ, Lobo RD, Luders C Abstract INTRODUCTION: Chronic hemodialysis (HD) patients are considered to be at high risk for infection. Here, we describe the clinical outcomes of chronic HD patients with influenza A (H1N1) infection and the strategies adopted to control an outbreak of influenza A in a dialysis unit. METHODS: Among a total of 62 chronic HD patients, H1N1 infection was identified in 12 (19.4%). Of the 32 staff members, four (12.5%) were found to be infected with the H1N1 virus. Outcomes included symptoms at presentation, comorbidities, occurrence of hypoxemia, hospit...
Source: Jornal Brasileiro de Nefrologia - Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research
Condition:   Non-alcoholic Fatty Liver Disease (NAFLD) Interventions:   Drug: Metabolic Cofactor Supplementation;   Drug: Sorbitol Sponsors:   ScandiBio Therapeutics AB;   Koç University;   Koç University Hospital;   Göteborg University;   Sahlgrenska University Hospital, Sweden;   KTH Royal Institute of Technology;   University of Helsinki;   Helsinki University Central Hospital;   Monitor CRO Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Obesity;   Surgery;   Anesthesia Intervention:   Other: no intervention Sponsor:   University of Vermont Medical Center Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Obesity-Associated Insulin Resistance Intervention:   Drug: Moxonidine Sponsor:   Italo Biaggioni Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Obesity, Childhood Intervention:   Sponsor:   Centre Hospitalier Universitaire de la Réunion Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Purpose of review To review the evidence regarding a decrease in worldwide sperm parameters and discuss potential causative factors. Recent findings The topic of worldwide decline in sperm parameters is contentious; however, recent high-quality studies have demonstrated that there is indeed a decline in sperm parameters. Several retrospective and basic science studies have shown possible links for this decline in sperm parameters such as obesity, diet, and environmental toxins. Summary There exist substantial data to suggest a decline in sperm counts over time. Although causative factors have yet to be fully elucid...
Source: Current Opinion in Urology - Category: Urology & Nephrology Tags: GENDER MEDICINE, INFERTILITY AND ERECTILE FUNCTION: Edited by Ryan Flannigan and Ranjith Ramasamy Source Type: research
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