Vaccines can prevent fatal complications from measles, study affirms

Measles may lead to serious, fatal complications not often associated with the disease, a new study finds.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news

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We report a child homozygous for a genomic deletion of the entire coding sequence and part of the 3’U TR of the last exon of IFNAR1, who died from HSE at the age of two years. An older cousin died following vaccination against measles, mumps and rubella at 12 months of age, and another 17-year-old cousin homozygous for the same variant has had other viral illnesses. The encoded IFNAR1 protein is exp ressed on the cell surface but is truncated and cannot interact with the tyrosine kinase TYK2. The patient’s fibroblasts and EBV-B cells did not respond to IFN-α2b or IFN-β, in terms of STAT1, STAT2 and S...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Measles (rubeola) is a highly contagious infectious disease with significant morbidity/mortality. Measles-Mumps-Rubella (MMR) is a live-attenuated vaccine used in the United States (US) to prevent measles. This retrospective longitudinal cohort study evaluated childhood MMR vaccination and the risk of a seizure episode and seizure disorder.
Source: Brain and Development - Category: Neurology Authors: Tags: Original article Source Type: research
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Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Covid-19 Boston, MA Health Healthcare Status Healthwatch Syndicated Local Coronavirus Dr. Mallika Marshall Source Type: news
This article provides an expert opinion by Dr. Paul A. Offit a renowned and highly respected pediatric infectious disease physician, to consider non-vaccination of healthy children as a form of neglect.
Source: Journal of Child and Adolescent Trauma - Category: Child Development Source Type: research
ák L, Németh P, Berki T Abstract BACKGROUND: Infection or vaccine-induced T cell-dependent immune response and the subsequent high affinity neutralizing antibody production have been extensively studied, while the connection between natural autoantibodies (nAAbs) and disease-specific antibodies has not been thoroughly investigated. Our goal was to find relationship between IgM and IgG isotype nAAbs and infection or vaccine-induced and disease-related autoantibody levels in systemic autoimmune diseases (SAD). METHODS: A previously described indirect ELISA test was used for detection of IgM/IgG nA...
Source: Clinical and Developmental Immunology - Category: Allergy & Immunology Authors: Tags: Clin Exp Immunol Source Type: research
CONCLUSIONS: Linking family assistance payments with childhood vaccination status and associated program improvements were followed by substantial catch-up vaccination activity, particularly in young people from families of lower socio-economic status. PMID: 32951230 [PubMed - as supplied by publisher]
Source: Med J Aust - Category: General Medicine Authors: Tags: Med J Aust Source Type: research
We describe the clinical presentation and outcome of hospitalized patients during the outbreak.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: 0633 Source Type: research
r U Abstract Measles outbreaks occur rather frequently in Germany. Patients with chronic inflammatory diseases are often treated with immunosuppressants. A recent study showed that about 7% of such patients are not protected against measles according to the lack of documentation in the vaccination card or the absence of protective antibodies. The Standing Committee on Immunization (STIKO) recommends a first vaccination against measles as a measles-mumps-rubella combined vaccination (MMR) in children aged 11-14 months and a second vaccination at 14-23 months. For adults born after 1970, vaccination against measles ...
Source: Zeitschrift fur Rheumatologie - Category: Rheumatology Authors: Tags: Z Rheumatol Source Type: research
History illustrates the remarkable public health impact of mass vaccination, by dramatically improving life expectancy and reducing the burden of infectious diseases and co-morbidities worldwide. It has been perceived that if an individual adhered to the MMR vaccine schedule that immunity to mumps virus (MuV) would be lifelong. Recent mumps outbreaks in individuals who had received two doses of the Measles Mumps Rubella (MMR) vaccine has challenged the efficacy of the MMR vaccine. However, clinical symptoms, complications, viral shedding and transmission associated with mumps infection has been shown to be reduced in vacci...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Background: In 2000, endemic measles was declared eliminated in the US. However, a proliferation of anti-vaccination sentiment over the last decade has led to measles ’ re-emergence, with 2019 experiencing the most measles cases in the US since 1992. Rising rates of non-medical exemptions (NMEs) and low vaccination coverage in the state of Michigan prompted an administrative vaccine policy change in 2015, mandating that parents attend an in-person vaccine educa tion session prior to obtaining a non-medical exemption waiver.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: 0565 Source Type: research
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