Physical activity in myotonic dystrophy type 1

The objective of this study is to assess physical activity and predictors of physical activity in individuals with DM1.MethodsSixty-seven adults with DM1 and 39 healthy adults were recruited. Physical activity was monitored by accelerometry and assessed using the International Physical Activity Questionnaire. Age, marital status, education, apathy, cognition, fatigue, and muscle strength were assessed as predictors of physical activity in DM1.ResultsThe individuals with DM1 were on average − 187 min (p 
Source: Journal of Neurology - Category: Neurology Source Type: research

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Popular documentary representations of crime and punishment have traditionally tended to fall into two camps: programs that are critical of law enforcement agencies and those that are sympathetic to them. In this article, we show how programs that present ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Commentary Source Type: news
PMID: 32246770 [PubMed - as supplied by publisher]
Source: The Journal of Physiology - Category: Physiology Authors: Tags: J Physiol Source Type: research
AbstractPurpose of ReviewThere is substantial inter-individual variability in body weight change, which is not fully accounted by differences in daily energy intake and physical activity levels. The metabolic responses to short-term perturbations in energy intake can explain part of this variability by quantifying the degree of metabolic “thriftiness” that confers more susceptibility to weight gain and more resistance to weight loss. It is unclear which metabolic factors and pathways determine this human “thrifty” phenotype. This review will investigate and summarize emerging research in the field o...
Source: Current Obesity Reports - Category: Eating Disorders & Weight Management Source Type: research
AbstractPrevious studies demonstrated the benefits of motor exercise and physical activity in neuromuscular disorders. However, very few papers assessed the effects of sport practise. The aim of this multicentre study was to assess the impact of sport activity on self-esteem and emotional regulation in a cohort of athletes with neuromuscular disorders. The 38 patients with Duchenne, Becker or other types of muscular dystrophy or spinal muscular atrophy practising sport (aged 13 –49 years) and 39 age-, gender-, disability- and disease-matched patients not practising sport were enrolled. Testing procedures to asse...
Source: Neurological Sciences - Category: Neurology Source Type: research
Conclusion: This meta-analysis supports the concept of RDN as an adjunctive treatment for atrial fibrillation. Further studies with standardized PVI and RDN procedures are needed.
Source: Journal of Hypertension - Category: Cardiology Tags: REVIEWS AND META-ANALYSES Source Type: research
Conclusion: Extreme dipping pattern is a BP phenotype highly frequent in the general population largely consisting of middle-aged individuals without prevalent cardiovascular disease. In this population, the extreme dipping pattern is not associated with an increased risk of cardiac HMOD, which suggests that the mechanisms invoked for the potential adverse cardiovascular effects of this condition (i.e. nocturnal hypoxemia, low-grade myocardial inflammation, coronary hypoperfusion, sympathetic activation at early morning, etc.) are not operative.
Source: Journal of Hypertension - Category: Cardiology Tags: ORIGINAL PAPERS: Organ damage Source Type: research
Conclusion: Taken together, our results suggest that exciting the CB2 receptor relieves proinflammatory cytokine levels in the RVLM to decrease the BP, HR and RSNA in SHRs.
Source: Journal of Hypertension - Category: Cardiology Tags: ORIGINAL PAPERS: Experimental animal models Source Type: research
In conclusion, upregulated prorenin in the RVLM may be involved in the pathogenesis of SIH, mediated by activation of the microglia-derived NLRP3 inflammasome. The link between prorenin and NLRP3 in microglia provides insights for the treatment of stress-related hypertension.
Source: Neuroscience Bulletin - Category: Neuroscience Source Type: research
Source: International Journal of Neuroscience - Category: Neuroscience Authors: Source Type: research
We examined changes in integrated muscle sympathetic nerve activity (MSNA) burst and multi-unit action potential (AP) recruitment patterns, as well as hemodynamic responses during cold pressor test (CPT) in 14 women with PTSD and 14 healthy controls. Data were collected during 1-min baseline, 2-min CPT, and 3-min recovery. At baseline, blood pressure (BP) were not different between groups; however, heart rate and sympathetic neural activity were greater in women with PTSD (MSNA burst frequency (BF): 27±13 vs. 18±14 bursts/min; P=0.04, AP frequency; 272±152 vs. 174±146 spikes/min; P=0.03). In res...
Source: American Journal of Physiology. Heart and Circulatory Physiology - Category: Physiology Authors: Tags: Am J Physiol Heart Circ Physiol Source Type: research
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