New computational tools identify alternative splicing changes in aggressive cancers

(Children's Hospital of Philadelphia) A multi-institutional group of researchers led by Children's Hospital of Philadelphia (CHOP) has linked a strong cancer driver gene to changes in proteins that regulate alternative splicing. The researchers created new computational tools and biological model systems for the study. This collaborative research, led by Yi Xing, PhD, at CHOP and Owen Witte, MD, at the University of California, Los Angeles (UCLA), was published today in the Proceedings of the National Academy of Sciences.

https://www.eurekalert.org/pub_releases/2020-02/chop-nct021220.php

Source: EurekAlert! - Cancer - February 17, 2020 Category: Cancer & Oncology Source Type: news