Long-lived regulatory T cells generated during severe bronchiolitis in infancy influence later progression to asthma

Mucosal Immunology, Published online: 17 February 2020; doi:10.1038/s41385-020-0268-8Long-lived regulatory T cells generated during severe bronchiolitis in infancy influence later progression to asthma
Source: Mucosal Immunology - Category: Allergy & Immunology Authors: Source Type: research

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CONCLUSIONS: Pneumovirus infection induces AEC necroptosis. Inhibition of necroptosis may be a viable strategy to limit the severity of viral bronchiolitis and break its nexus with asthma. PMID: 32105156 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - Category: Respiratory Medicine Authors: Tags: Am J Respir Crit Care Med Source Type: research
;nchez-Solis M, López-Hernández F Abstract INTRODUCTION: Urban air pollution is a major threat to child and adolescent health. Children are more vulnerable to its effects, being associated with higher morbidity and mortality due to acute and chronic diseases, especially respiratory ones. A study is performed on the relationship between urban air pollution and the rate of hospital admissions due to acute respiratory diseases. PATIENTS AND METHODS: An ecological study was conducted on young people under 17 years-old in the city of Murcia, who had visited hospital emergency departments due to respi...
Source: Anales de Pediatria - Category: Pediatrics Authors: Tags: An Pediatr (Barc) Source Type: research
This study also demonstrates that HRV infection upregulates PAD2 protein expression, and increases levels of protein citrullination, including histone H3, in human bronchial epithelial cells. Increased PADI gene expression and HDP citrullination during infection may represent a novel viral evasion mechanism, likely applicable to a wide range of pathogens, and should therefore be considered in the design of therapeutic peptide derivatives.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Infants hospitalized for bronchiolitis are at high-risk for developing recurrent wheeze and childhood asthma. Exposure to acid suppressant medications (ASMs), such as proton pump inhibitors and histamine-2 receptor antagonists, during infancy may increase risk of asthma. We tested the hypothesis that exposure to ASMs in infancy increases risk of recurrent wheeze among a high-risk population of children with a history of severe bronchiolitis.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
This article reviews the available literature on the field of RSV disease severity and discusses important factors associated to susceptibility and different disease outcome.Expert opinion: The severity of RSV-induced illness is a phenomenon that depends on a variety of graded mechanisms of interaction between the host, virus, and environment. This may lead to differences in intensity of immune response in the lung and different courses of the disease. By characterizing, classifying and grading the affecting factors in high-risk patients versus those who do not fall ill by RSV, we may find therapies or point to disease-lim...
Source: Expert Review of Respiratory Medicine - Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research
AbstractRespiratory viral infections are the most important triggers of asthma exacerbations. Rhinovirus (RV), the common cold virus, is clearly the most prevalent pathogen constantly circulating in the community. This virus also stands out from other viral factors due to its large diversity (about 170 genotypes), very effective replication, a tendency to create Th2-biased inflammatory environment and association with specific risk genes in people predisposed to asthma development (CDHR3). Decreased interferon responses, disrupted airway epithelial barrier, environmental exposures (including biased airway microbiome), and ...
Source: Seminars in Immunopathology - Category: Pathology Source Type: research
ConclusionsWe demonstrated lower TNF ‐α production by in vitro stimulated CD4+ T cells during severe RSV bronchiolitis in children that subsequently developed recurrent wheezing, compared with children with no subsequent wheeze. These findings support the role of CD4+ T cell immunity in the development of subsequent wheezing in thes e children.
Source: Immunity, Inflammation and Disease - Category: Allergy & Immunology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Authors: Underner M, Peiffer G, Perriot J, Jaafari N Abstract Cocaine can be responsible for many psychiatric and/or somatic disorders. The aim of this systematic literature review of data was to expose relations between cocaine use and pulmonary complications. Cocaine can be responsible for acute respiratory symptoms (cough, black sputum, hemoptysis, dyspnea, wheezing, chest pain) and for various pulmonary disorders including barotrauma (pneumothorax, pneumomediastinum, subcutaneous emphysema, pneumopericardium), airway damage, asthma, bronchiolitis obliterans with organizing pneumonia, acute pulmonary edema, alve...
Source: Revue des Maladies Respiratoires - Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research
DiscussionThis review will aid in determining if the relationship between RSV and asthma development is a causal one, by showing the effect (if any) of RSV prophylaxis on subsequent recurrent wheeze/asthma. If this study shows RSV prophylaxis to have no effect on the outcome of recurrent wheeze/asthma, the question of causality remains.
Source: Systematic Reviews - Category: International Medicine & Public Health Source Type: research
Conclusion: In infants and young children with bronchiolitis, HFNC may be an effective and pleasant alternative to CPAP. Larger multicenter studies are needed to further explore differences in treatment failure and treatment duration.Trial registration:www.clinicaltrial.gov. id NCT02618213, registration date December 1, 2015.What is Known:•CPAP has been used for many years for respiratory support in infant bronchiolitis. The method requires special staff skills and may be stressful to the child.• HFNC has been introduced as a newer tool.What is New:•In infants with bronchiolitis, HFNC and CPAP were comparabl...
Source: European Journal of Pediatrics - Category: Pediatrics Source Type: research
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