The Complex Role of Nociceptin Signaling in Stress: Clarity Through Neuroimaging?

Shortly after it became the first orphan G protein –coupled receptor successfully cloned, the eponymously named nociceptin opioid peptide/orphaninFQ receptor (NOPR) and its endogenous ligand (N/OFQ) were speculated to mediate behaviors beyond nociception (1). Given the high levels of expression of N/OFQ and NOPR in hypothalamic, limbic, and monoam inergic structures across the mammalian brain (2,3), focus quickly turned toward the investigation of how this novel opioidergic system regulated stress and affective behaviors, such as anxiety and depression.
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Commentary Source Type: research

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Authors: Mason TM, Tofthagen CS, Buck HG Abstract Complicated grief (CG) poses significant physical, psychological, and economic risks to bereaved family caregivers. An integrative review of the literature published 2009-2018 on CG associated with caregiving was performed using PubMed, PsychINFO, and Web of Science. The search returned 1428 articles, of which 32 were included in the review. Sixteen studies described risk and protective factors and 16 described interventions for CG. Caregiver-related risk factors included fewer years of education, depression, anxiety, poor physical health, and maladaptive dependency...
Source: Journal of Social Work in End-of-Life and Palliative Care - Category: Palliative Care Tags: J Soc Work End Life Palliat Care Source Type: research
CONCLUSION: New care models need to be developed to integrate mental health care into the current perioperative care practice. PMID: 32234274 [PubMed - as supplied by publisher]
Source: The American Journal of Geriatric Psychiatry - Category: Psychiatry Tags: Am J Geriatr Psychiatry Source Type: research
The ten best foods to feel more positive about life and have a lower risk of depression. → Support PsyBlog for just $5 per month. Enables access to articles marked (M) and removes ads. → Explore PsyBlog's ebooks, all written by Dr Jeremy Dean: Accept Yourself: How to feel a profound sense of warmth and self-compassion The Anxiety Plan: 42 Strategies For Worry, Phobias, OCD and Panic Spark: 17 Steps That Will Boost Your Motivation For Anything Activate: How To Find Joy Again By Changing What You Do
Source: PsyBlog | Psychology Blog - Category: Psychiatry & Psychology Authors: Tags: Mental Health Nutrition subscribers-only Source Type: blogs
CONCLUSION: Age, diabetes mellitus and the presence of voiding symptoms are factors associated with erectile dysfunction in the field of Primary Care. PMID: 32229028 [PubMed - as supplied by publisher]
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
This study aims to investigate the sociodemographic, clinical, and course differences between melancholic and non-melancholic depression. METHODS: This prospective observational study was carried out at Kasturba Hospital, Manipal, India from November 2010 to September 2011. We recruited consecutive inpatients aged 18 to 60 years who have a diagnosis of depressive disorder (based on ICD-10), with or without any psychiatric or physical comorbidities. Patients were categorised into melancholia and non-melancholia using the CORE questionnaire, with scores of ≥8 indicating the presence of melancholic depression. In addit...
Source: East Asian Archives of Psychiatry - Category: Psychiatry Tags: East Asian Arch Psychiatry Source Type: research
CONCLUSIONS: Lifetime TE and TE in psychiatric settings are common among patients with SMI. Trauma-informed care is suggested for mental health services. PMID: 32229641 [PubMed - in process]
Source: East Asian Archives of Psychiatry - Category: Psychiatry Tags: East Asian Arch Psychiatry Source Type: research
AbstractBackgroundEmotion regulation difficulties appear to play a role in the development and maintenance of several eating disorders. This pilot study aimed at examining whether a short add-on group skills training in emotion regulation for young adults with different eating disorders was feasible in a psychiatric clinical setting. We also investigated if the treatment increased knowledge of emotions, and decreased self-reported difficulties with emotion regulation, alexithymia, symptoms of eating disorder, anxiety and depression, as well as clinical impairment.MethodsSix skills training groups were piloted with a total ...
Source: Journal of Eating Disorders - Category: Eating Disorders & Weight Management Source Type: research
ConclusionsDigital ‐based cancer stress‐management interventions, such asStressProffen, have the potential to provide easily accessible, effective psychosocial support for cancer survivors.
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
AbstractAim of the studyWe assessed the role of personality traits, anxiety, and depression in residual pain among patients who underwent total hip (THA) and knee (TKA) arthroplasty.MethodEighty-three patients (40 THA and 43 TKA) were interviewed pre-operatively (t0); five  days (t1) after surgery; and one (t2), three (t3), six (t4), and 12  months (t5) after surgery. Personality (TCI-R), pain (VAS), anxiety and depression (HADS), quality of life (SF-12), functionality (HHS/KSS), and disability (WOMAC) were evaluated.ResultsPain reduction and functional improvement were reported at t5 (bothp 
Source: International Orthopaedics - Category: Orthopaedics Source Type: research
In conclusion, MDR is more effective than either sham treatment or usual care in the short-term improvement of pain and the physical wellbeing of participants with fibromyalgia.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
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