Trial By Error: My Follow-up Letter to Mahana Therapeutics ’ CEO

By David Tuller, DrPH Last week, I wrote to Rob Paull, the co-founder and CEO of Mahana Therapeutics, regarding the company’s misleading claims about the web-based cognitive behavior therapy program for irritable bowel syndrome it recently licensed from King’s College London. I have also written to Professor Rona Moss-Morris, the co-lead investigator of ACTIB, the […]
Source: virology blog - Category: Virology Authors: Tags: Uncategorized Source Type: blogs

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By David Tuller, DrPH I have been trying to find out why Mahana Therapeutics, a San Francisco-based start-up, has chosen to disseminate misleading information about a web-based cognitive behavior therapy program for people with irritable bowel syndrome. Because Mahana’s co-founder and CEO, Rob Paull, has not responded to my letters, I have contacted some of […]
Source: virology blog - Category: Virology Authors: Tags: Uncategorized Source Type: blogs
By David Tuller, DrPH Ten days ago, I sent a letter to Professor Rona Moss-Morris of King’s College London, seeking information about the licensing deal involving her web-based program of cognitive behavior therapy to treat irritable bowel syndrome. Since I have not heard back, this morning I made a second attempt to reach out to […]
Source: virology blog - Category: Virology Authors: Tags: Uncategorized Source Type: blogs
Irritable bowel syndrome (IBS) is a common disease that affects the quality of life (QOL) and social functioning of sufferers. Visceral anxiety is currently considered a key factor in the onset and exacerbatio...
Source: BMC Gastroenterology - Category: Gastroenterology Authors: Tags: Study protocol Source Type: research
By David Tuller, DrPH Last week I wrote about the recently announced licensing deal between Mahana Therapeutics and King’s College London. The deal involves a web-based course of cognitive behavior therapy designed to treat irritable bowel syndrome. In a major study, the reported improvements in symptoms among participants in the web-based program were modest at […]
Source: virology blog - Category: Virology Authors: Tags: Uncategorized Source Type: blogs
Patients in remission from inflammatory bowel disease are susceptible to irritable bowel syndrome, but diet, cognitive therapy, and medication can help treat the symptoms.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Gastroenterology News Source Type: news
CONCLUSIONS: There is currently not enough evidence to assess whether biofeedback interventions are effective for controlling symptoms of IBS. Given the positive results reported in small trials to date, biofeedback deserves further study in people with IBS. Future research should include active control groups that use high provider-participant interaction, in an attempt to balance non-specific effects of interventions between groups, and report both commonly used outcome measures (e.g. IBS-SSS) and historical outcome measures (e.g. the composite primary symptom reduction (CPSR) score) to allow for meta-analysis with previ...
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
Everitt HA, Landau S, O ’Reilly G, et al. Assessing telephone-delivered cognitive-behavioural therapy (CBT) and web-delivered CBT versus treatment as usual in irritable bowel syndrome (ACTIB): a multicentre randomised trial. Gut 2019;0:1-11.
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Selected Summaries Source Type: research
Mean IBS Symptom Severity Score reduced for telephone - , web - CBT versus treatment as usual
Source: The Doctors Lounge - Psychiatry - Category: Psychiatry Tags: Family Medicine, Gastroenterology, Internal Medicine, Psychiatry, Journal, Source Type: news
This study aimed to compare dialectical behavior therapy (DBT), mindfulness based cognitive therapy (MBCT) and positive psychotherapy (PPT) effects on perceived stress (PS) and quality of life (QOL) among patients with irritable bowel syndrome (IBS). Seventy six eligible patients with a Rome- IV diagnosis were randomly allocated in DBT (n = 18), MBCT (n = 20), PPT (n = 18), and control groups (n = 20). All the patients were evaluated for PS by perceived stress scale (PSS) and QOL by irritable bowel syndrome quality of life (IBS-QOL) on the studied groups at the time o...
Source: Psychiatric Quarterly - Category: Psychiatry Source Type: research
Abstract Irritable bowel syndrome (IBS) is a functional gastrointestinal syndrome consisting of different bowel pattern subtypes: diarrhea predominant (IBS-D), constipation predominant (IBS-C), and alternating (IBS-A). This paper aimed to identify whether (a) psychological factors implicated in the cognitive behavioral model of IBS were differentially associated with bowel pattern subtypes, (b) whether there were differences in symptom severity and work and social adjustment across the IBS-subtypes. Analysis was conducted on baseline data of 557 individuals with refractory IBS recruited into the Assessing Cognitiv...
Source: Behavior Therapy - Category: Psychiatry & Psychology Authors: Tags: Behav Ther Source Type: research
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