Effects of chemotherapy on the auditory system of children with cancer: a systematic literature review

Conclusion: there is evidence that both carboplatin and especially cisplatin from the first doses may impair the hearing of children and adolescents, mainly affecting the cochlear function, thus, the importance of long-term audiological monitoring.RESUMO Objetivo: identificar e analisar os efeitos da quimioterapia no sistema auditivo de crian ças e/ou adolescentes com câncer tratados com cisplatina e carboplatina, avaliados por meio de procedimentos audiológicos padronizados. Métodos: buscou-se por estudos nos idiomas português brasileiro e inglês, disponíveis nas bases de dados Science Direct, PubMed, Lilacs, Bireme, Embase, Sci elo, Web of Science e Cochrane. Os descritores foram: Perda Auditiva, Audiologia, Câncer Infantil, Quimioterapia e Criança. Foram considerados artigos com níveis de evidência científica 1 e 2, publicados nos últimos 20 anos (1997 a 2017), dos quais foram analisados os resultados audiológicos, bem como a prevalência da perda auditiva de crianças com câncer submetidas à quimioterapia. Resultados: foram encontrados 3625 artigos, sendo que apenas 23 foram selecionados para análise na presente revisão. Os estudos demonstraram alta incidência de perda auditiva neurossensorial e diminu ição ou até perda das emissões otoacústicas em crianças e adolescentes com câncer, mesmo ...
Source: Revista CEFAC - Category: Speech-Language Pathology Source Type: research

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We’re tackling a few urgent questions from parents in this time of coronavirus and COVID-19. Are you wondering if babies and children should continue to have vaccines on schedule? Thinking about how to manage regular medical appointments, and which situations require in-person visits to a pediatric practice? Read on. Should parents take babies for initial vaccines right now? What about toddlers and older children who are due for vaccines? The answer to this question is going to depend on many factors, including what your doctor’s office is offering. As with all health care decisions, it comes down to weighing r...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Adolescent health Children's Health Health care Parenting Vaccines Source Type: blogs
Authors: Ingley KM, Cohen-Gogo S, Gupta AA Abstract Soft-tissue sarcoma (sts) is rare and represents approximately 7% of cancers in children and in adolescents less than 20 years of age. Rhabdomyosarcoma (rms) is most prevalent in children less than 10 years of age and peaks again during adolescence (16-19 years of age). Multi-agent chemotherapy constitutes the mainstay of treatment for rms. In other non-rhabdomyosarcoma soft-tissue tumours, such as synovial sarcoma, evidence for routine use of chemotherapy is less robust, and alternative treatment options, including targeted agents and immunotherapy, are being exp...
Source: Current Oncology - Category: Cancer & Oncology Tags: Curr Oncol Source Type: research
CONCLUSION: The treatment approach used is well tolerated by adult patients. However, the AYA patients and particularly adolescent subgroup had more advanced disease at diagnosis and should be treated more intensively in dedicated units. RT dose
Source: Cancer Radiotherapie - Category: Cancer & Oncology Authors: Tags: Cancer Radiother Source Type: research
Conclusion: We only opted for a treatment-sparing approach for patients with severe disabilities, and their OS was in line with that of children without intellectual disability.What is Known:• There are few reports on children/adolescents with cancer and intellectual disability (ID).• It is not clear how to manage them and whether a treatment sparing should be considered, especially in the case of severe disability.What is New:• Most patients received the standard cancer treatment and only in the case of severe disability, a therapeutic saving approach was applied.• No statistically significant correlat...
Source: European Journal of Pediatrics - Category: Pediatrics Source Type: research
“I felt like I was helping myself stay healthy.” Bike to Fight is placing exercise bikes on adolescent and young adult oncology floors in hospitals nationwide.
Source: Washington Post: To Your Health - Category: Consumer Health News Authors: Source Type: news
This reported case of cardiac rhabdomyosarcoma is the first case to be successfully treated with eribulin over a relatively long period. Eribulin therapy may thus be a viable treatment alternative for rhabdomyosarcoma.
Source: Anti-Cancer Drugs - Category: Cancer & Oncology Tags: Case Reports Source Type: research
Abstract Osteosarcoma is an aggressive bone cancer found in children and adolescents. The surgical removal of tumour and chemotherapy combined treatment for osteosarcoma has been widely accepted approach. However, the drug resistance developed by tumour cells resulted in recurrence of cancer. It is imperative to understand the molecular mechanism involved in the development of drug resistance and tumour progression for developing potential therapy. Tumour microenvironment and cellular cross talk via activation of various signalling pathways are responsible for tumour progression and metastasis. The comprehend revi...
Source: Current Drug Metabolism - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Metab Source Type: research
g M Abstract BACKGROUND: Chemotherapy-induced nausea and vomiting (CINV) is a severe and distressing complication during allogeneic hematopoietic stem cell transplantation (alloHSCT). The antiemetic fosaprepitant has shown favorable results in pediatric and adult patients receiving chemotherapy. Data on fosaprepitant in children and adolescents undergoing alloHSCT are missing. METHODS: In this non-interventional observation study, 120 children and adolescents with a median age of 11.8 years undergoing alloHSCT after a moderately or highly emetogenic conditioning (MEC or HEC) were analyzed. They received ...
Source: Clin Med Res - Category: Research Authors: Tags: J Cancer Res Clin Oncol Source Type: research
AbstractBackground Chemotherapy-induced nausea and vomiting (CINV) is a severe and distressing complication during allogeneic hematopoietic stem cell transplantation (alloHSCT). The antiemetic fosaprepitant has shown favorable results in pediatric and adult patients receiving chemotherapy. Data on fosaprepitant in children and adolescents undergoing alloHSCT are missing.MethodsIn this non-interventional observation study, 120 children and adolescents with a median age of 11.8  years undergoing alloHSCT after a moderately or highly emetogenic conditioning (MEC or HEC) were analyzed. They received an antiemetic prophy...
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
Conclusions: Our results suggest performing mutational screening for colorectal cancer also in the pediatric setting, in order to orient treatment that should include targeted therapies.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Case Report Source Type: research
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