Effects of chemotherapy on the auditory system of children with cancer: a systematic literature review

Conclusion: there is evidence that both carboplatin and especially cisplatin from the first doses may impair the hearing of children and adolescents, mainly affecting the cochlear function, thus, the importance of long-term audiological monitoring.RESUMO Objetivo: identificar e analisar os efeitos da quimioterapia no sistema auditivo de crian ças e/ou adolescentes com câncer tratados com cisplatina e carboplatina, avaliados por meio de procedimentos audiológicos padronizados. Métodos: buscou-se por estudos nos idiomas português brasileiro e inglês, disponíveis nas bases de dados Science Direct, PubMed, Lilacs, Bireme, Embase, Sci elo, Web of Science e Cochrane. Os descritores foram: Perda Auditiva, Audiologia, Câncer Infantil, Quimioterapia e Criança. Foram considerados artigos com níveis de evidência científica 1 e 2, publicados nos últimos 20 anos (1997 a 2017), dos quais foram analisados os resultados audiológicos, bem como a prevalência da perda auditiva de crianças com câncer submetidas à quimioterapia. Resultados: foram encontrados 3625 artigos, sendo que apenas 23 foram selecionados para análise na presente revisão. Os estudos demonstraram alta incidência de perda auditiva neurossensorial e diminu ição ou até perda das emissões otoacústicas em crianças e adolescentes com câncer, mesmo ...
Source: Revista CEFAC - Category: Speech-Language Pathology Source Type: research

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Cancers, Vol. 12, Pages 2815: DUX Hunting—Clinical Features and Diagnostic Challenges Associated with DUX4-Rearranged Leukaemia Cancers doi: 10.3390/cancers12102815 Authors: Jacqueline A. Rehn Matthew J. O'Connor Deborah L. White David T. Yeung DUX4-rearrangement (DUX4r) is a recently discovered recurrent genomic lesion reported in 4–7% of childhood B cell acute lymphoblastic leukaemia (B-ALL) cases. This subtype has favourable outcomes, especially in children and adolescents treated with intensive chemotherapy. The fusion most commonly links the hypervariable IGH gene to DUX4 a gene loca...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
In conclusion, we have shown that the osteosarcoma PDX model reliably recapitulates the morphological aspects of the human disease after serial passage in mice. The observation that more aggressive forms of osteosarcoma, including those with metastatic disease at presentation, have a higher efficiency to generate PDXs provides a promising scenario to address several unanswered issues in clinical oncology. PMID: 32964941 [PubMed - as supplied by publisher]
Source: Histology and Histopathology - Category: Cytology Tags: Histol Histopathol Source Type: research
AbstractPurpose of ReviewThe goal of this systematic review is to analyze the effectiveness of bisphosphonates (BPs) to treat bone pain in children and adolescents who have diseases with skeletal involvement.Recent FindingsWe included 24 studies (2 randomized controlled trials, 3 non-randomized controlled trials, 10 non-randomized open-label uncontrolled studies, 8 retrospective studies, and 1 study with design not specified). The majority of included studies assessed pain from a unidimensional approach, with pain intensity the most frequently evaluated dimension. Only 38% of studies used validated tools; visual analogue s...
Source: Current Osteoporosis Reports - Category: Orthopaedics Source Type: research
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Most sarcomas occur in the adolescent and young adult (AYA) population, ages 15-39, but compared to both children and older adults, the AYA population is under enrolled on clinical trials. It was hypothesized that the National Cancer Database (NCDB) could detect factors influencing receipt of chemotherapy (CHT) and/or radiation therapy (RT) before or after limb-sparing surgery for extremity soft tissue sarcomas (ESS) that were unique to AYAs compared to other adults.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Source Type: research
The objective of this analysis is to detail current knowledge regarding ENBs' epidemiological, biological, clinical and radiological characteristics as well as how to manage ENB in young patients. PMID: 32896369 [PubMed - as supplied by publisher]
Source: Bulletin du Cancer - Category: Cancer & Oncology Authors: Tags: Bull Cancer Source Type: research
AbstractPurposePrescribing guideline-recommended anti-emetics is an effective strategy to prevent CINV. However, the rate of guideline-concordant care is not well-understood. The purpose of this study was to describe the proportion of pediatric, adolescent, and young adult patients receiving HEC or MEC who received guideline-concordant antiemetic prophylaxis for acute CINV and to identify potential predictors of guideline-concordant antiemetic prophylaxis.MethodsUsing electronic health record data from 2016 through 2018, a retrospective single-institution cohort study was conducted to investigate how often patients less th...
Source: Supportive Care in Cancer - Category: Cancer & Oncology Source Type: research
Authors: Collier CD, Getty PJ, Greenfield EM Abstract Epigenetic deregulation is an emerging hallmark of cancer that enables tumor cells to escape surveillance by tumor suppressors and ultimately progress. The structure of the epigenome consists of covalent modifications of chromatin components, including acetylation by histone acetyltransferases (HATs) and deacetylation by histone deacetylases (HDACs). Targeting these enzymes with inhibitors to restore epigenetic homeostasis has been explored for many cancers. Osteosarcoma, an aggressive bone malignancy that primarily affects children and young adults, is notable ...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
AbstractPurposeThe study objective was to assess the discussion of late effects (LEs) and screening recommendations (SRs) for adolescent and young adults (AYAs) treated for lymphoma.MethodsA retrospective study was conducted on AYA lymphoma survivors aged 15 –24 years at diagnosis who received radiation therapy (RT) ± chemotherapy between 1984 and 2010 at any of the six British Columbia (BC) Cancer treatment centers across the province. Charts were reviewed to evaluate discussion of LEs and SRs. Susceptibility to specific LEs was determined by revie wing treatment details.ResultsOf 305 patients, 212 (70%)...
Source: Journal of Cancer Survivorship - Category: Cancer & Oncology Source Type: research
According to the National Cancer Institute, ∼300,000 children globally are diagnosed with cancer each year. Advancements in chemotherapy and radiotherapy have revolutionized cancer treatment and improved long-term survival. Although many survivors will remain in good health with disease-free prognoses, three fourths will experience short-term and long-term effects from treatment. The cancer care paradigm has now appropriately shifted to include quality of life in survivorship with fertility cited as one of the most important quality of life indicators by survivors. A comprehensive approach to fertility preservation in ...
Source: Clinical Obstetrics and Gynecology - Category: OBGYN Tags: Pediatric and Adolescent Gynecology: What the Generalist Ob/Gyn Needs to Know Source Type: research
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