Publisher Correction: Immunological adaptations in pregnancy that modulate rheumatoid arthritis disease activity

Nature Reviews Rheumatology, Published online: 17 February 2020; doi:10.1038/s41584-020-0394-4Publisher Correction: Immunological adaptations in pregnancy that modulate rheumatoid arthritis disease activity
Source: Nature Reviews Rheumatology - Category: Rheumatology Authors: Source Type: research

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AbstractThe dysregulation of the JAK –STAT pathway is associated with various immune disorders. Four JAK inhibitors have been approved for rheumatoid arthritis (RA), and numerous JAK inhibitors are currently being tested in phase II and III trials for the treatment of various autoimmune inflammatory diseases. In this narrative review , we elucidate the involvement of the JAK–STAT signaling pathway in the pathogenesis of connective tissue diseases (CTDs). We also discuss the efficacy of the first- and second-generation JAK inhibitors (tofacitinib, baricitinib, ruxolitinib, peficitinib, filgotinib, upadacitinib, ...
Source: Clinical Reviews in Allergy and Immunology - Category: Allergy & Immunology Source Type: research
CONCLUSION: The incidence of APS differs according to age groups and gender. The incidence of primary APS was higher than that of secondary APS in both gender. Furthermore, as already reported, secondary APS is highly associated with SLE; however, we observed that rheumatoid arthritis is also highly related. PMID: 32030922 [PubMed - in process]
Source: Journal of Korean Medical Science - Category: Biomedical Science Tags: J Korean Med Sci Source Type: research
Women with rheumatoid arthritis (RA) who adhere to an ideal clinical pathway have similar pregnancy outcomes as women in the general population, new findings show.Reuters Health Information
Source: Medscape Orthopaedics Headlines - Category: Orthopaedics Tags: Rheumatology News Source Type: news
Nature Reviews Rheumatology, Published online: 13 January 2020; doi:10.1038/s41584-019-0351-2Successful pregnancy requires changes to the immune system to enable tolerance of the growing fetus. In this Review, the authors discuss how these immunomodulatory mechanisms contribute to the phenomenon of pregnancy-related improvement of rheumatoid arthritis.
Source: Nature Reviews Rheumatology - Category: Rheumatology Authors: Source Type: research
WEDNESDAY, Jan. 8, 2020 -- For women with rheumatoid arthritis (RA), adherence to an ideal clinical pathway during pregnancy is associated with a reduced risk for miscarriage and complicated birth, according to a study published online Jan. 7 in...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
(Wiley) For women with rheumatoid arthritis (RA), taking certain steps to ensure that they have a healthy pregnancy leads to a reduced risk of complicated birth or miscarriage, according to a study in Arthritis Care&Research.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
CONCLUSIONS: In half cases, it was decided to stop biologic therapy in the family planning period. Using biologic disease-modifying anti-rheumatic drugs before and/or during pregnancy doesn't seem to affect the overall maternal and fetal outcomes. Pregnancy planning and treatment options should be discussed and a shared decision should be established between physician and patient. PMID: 32008032 [PubMed - as supplied by publisher]
Source: Acta Reumatologica Portuguesa - Category: Rheumatology Authors: Tags: Acta Reumatol Port Source Type: research
Domenico Plantone, Carlo Piantadosi, Serena Ruggieri, Vincenzo Anelli, Tatiana KoudriavtsevaNeurology India 2019 67(6):1519-1521 Until now, only one gestational tumefactive demyelinating lesion (TDL) has been described. Here we report two TDL cases occurring during and after the pregnancy. A 26-year-old 6-week pregnant woman developed a 3-cm left frontotemporoparietal subcortical TDL with inhomogeneous partial enhancement. Brain biopsy revealed a subacute demyelinating lesion with abundant macrophages and mild chronic perivascular inflammatory infiltrates. She also had femoralpopliteal deep vein thrombosis. During the 4-y...
Source: Neurology India - Category: Neurology Authors: Source Type: research
Publication date: Available online 13 December 2019Source: The Egyptian RheumatologistAuthor(s): Maryam Ahmed Abdulrahman, Samah A. Elbakry, Nagham Safwat Samy, Rehab M. Abdelrahman, Nermeen SamyAbstractBackgroundFemale patients with rheumatoid arthritis (RA) can have successful pregnancies. However, those who experience a higher disease activity during pregnancy and require continued treatment have a potential risk of maternal and neonatal complications.Aim of the workTo assess pregnancy outcome (adverse maternal and neonatal outcomes) in an Egyptian cohort of female RA patients.Patients and methodsThiscross-sectional stu...
Source: The Egyptian Rheumatologist - Category: Rheumatology Source Type: research
Publication date: Available online 2 December 2019Source: Best Practice &Research Clinical Endocrinology &MetabolismAuthor(s): Jamilya Khizroeva, Cecilia Nalli, Victoria Bitsadze, Andrea Lojacono, Sonia Zatti, Laura Andreoli, Angela Tincani, Yehuda Shoenfeld, Alexander MakatsariyaAbstractInfertility consists by definition in ” failure to achieve a clinical pregnancy after 12 months or more of regular unprotected intercourse” while the term subfertility means a delay to achieve pregnancy. Several factors can contribute to infertility or subfertility in patients with systemic autoimmune diseases. The asso...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - Category: Endocrinology Source Type: research
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