Sniff test: does what we measure at the nose reflect what happens in the chest wall?

AbstractThe strength of respiratory muscles is measured in terms of pressure, being the gradient that moves flow/volume to ventilate the lungs.Sniff test is a technically simple voluntary test that quantifies the strength of inspiratory muscles. Sniff nasal inspiratory pressure (SNIP)1 is a non ‐invasive parameter extensively used in the clinical, being considered more natural and pleasant than maximal inspiratory pressure measurements. It solves the possible leak problems of the use of a mouthpiece, particularly in neuromuscular patients2,3. In amyotrophic lateral sclerosis, for example, SNIP is a predictor of survival and tracheostomy4,5.
Source: The Clinical Respiratory Journal - Category: Respiratory Medicine Authors: Tags: LETTER TO THE EDITOR Source Type: research

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Publication date: Available online 8 April 2020Source: Pharmacological ResearchAuthor(s): Yam Nath Paudel, Efthalia Angelopoulou, Christina Piperi, Iekhsan Othman, Mohd. Farooq Shaikh
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
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Source: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration - Category: Neurology Authors: Source Type: research
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Source: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration - Category: Neurology Authors: Source Type: research
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Source: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration - Category: Neurology Authors: Source Type: research
AbstractObjectiveTo evaluate phrenic nerve motor amplitude (PhrenicAmp) as an independent predictor of functional decline in amyotrophic lateral sclerosis (ALS). We also assessed both PhrenicAmp and forced vital capacity (FVC) as predictors of functional loss in patients with bulbar dysfunction.MethodsWe included consecutive ALS patients with PhrenicAmp and FVC at baseline. Participants were evaluated with the revised ALS Functional Rating Scale (ALSFRS-R) at inclusion and at, at least, one subsequent follow-up visit. The outcome measure of functional decline was the percentage reduction in ALSFRS-R from baseline. Bulbar d...
Source: Journal of Neurology - Category: Neurology Source Type: research
Authors: Hergesheimer R, Lanznaster D, Vourc'h P, Andres C, Bakkouche S, Beltran S, Blasco H, Corcia P, Couratier P Abstract Introduction: To date, riluzole and edaravone are the only two drugs that have successfully passed clinical trials for the treatment of Amyotrophic Lateral Sclerosis (ALS). Unfortunately, both drugs exhibit very modest effects. Most other drugs have failed at phase III to show significant effects in phase III when tested in larger cohorts. This pattern necessitates improvements in the approach to ALS pharmacotherapy.Areas covered: The authors discuss the two approved drugs, as well as several...
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research
ie Lei Wang Neuro-degenerative disease is a common progressive nervous system disorder that leads to serious clinical consequences. Gait rhythm dynamics analysis is essential for evaluating clinical states and improving quality of life for neuro-degenerative patients. The magnitude of stride-to-stride fluctuations and corresponding changes over time—gait dynamics—reflects the physiology of gait, in quantifying the pathologic alterations in the locomotor control system of health subjects and patients with neuro-degenerative diseases. Motivated by algebra topology theory, a topological data analysis...
Source: Sensors - Category: Biotechnology Authors: Tags: Article Source Type: research
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Source: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration - Category: Neurology Authors: Source Type: research
Authors: Khosravi S, Harner ME Abstract Mitochondria perform a plethora of functions in various cells of different tissues. Their architecture differs remarkably, for instance in neurons versus steroidogenic cells. Furthermore, aberrant mitochondrial architecture results in mitochondrial dysfunction. This indicates strongly that mitochondrial architecture and function are intimately linked. Therefore, a deep knowledge about the determinants of mitochondrial architecture and their function on a molecular level is of utmost importance. In the past decades, various proteins and protein complexes essential for formatio...
Source: Biological Chemistry - Category: Chemistry Tags: Biol Chem Source Type: research
IN VITRO AND IN VIVO MODELS OF AMYOTROPHIC LATERAL SCLEROSIS: AN UPDATED OVERVIEW. Brain Res Bull. 2020 Apr 02;: Authors: Gois AM, Mendonça DMF, Freire MAM, Santos JR Abstract Amyotrophic Lateral Sclerosis (ALS) is a progressive, neurodegenerative disease characterized by loss of upper motor neurons (UMN) and lower motor neurons (LMN). Disease affects people all over the world and is more prevalent in men. Patients with ALS develop extensive muscle wasting, paralysis and ultimately death, with a median survival of usually fewer than five years after disease onset. ALS may be sporadic (sALS, 90%...
Source: Brain Research Bulletin - Category: Neurology Authors: Tags: Brain Res Bull Source Type: research
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