Feasibility Study to Evaluate RECELL and Melanocyte Keratinocyte Transplantation Procedure for Repigmentation of Stable Vitiligo Lesions

Condition:   Vitiligo Interventions:   Procedure: Melanocyte-Keratinocyte Transplantation and Ultraviolet Lamp (UVA);   Device: RECELL 1:5 and Ultraviolet Lamp (UVA);   Device: RECELL 1:10 and Ultraviolet Lamp (UVA);   Device: RECELL 1:20 and Ultraviolet Lamp (UVA) Sponsor:   Avita Medical Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Source Type: research
Conclusions: The results of our study show that transplantation of autologous hair follicle cells is a simple and effective method to treat patients with stable vitiligo. Hair follicles (especially the outer root sheath) harbor many melanocytes with potential proliferative ability. Limitations: There are a few limitations of the present study: a small sample size, a short follow-up period, no cell counting or viability testing.
Source: Indian Journal of Dermatology, Venereology and Leprology - Category: Dermatology Authors: Source Type: research
Condition:   Vitiligo Interventions:   Procedure: Melanocyte-Keratinocyte Transplantation and Ultraviolet Lamp (UVA);   Device: RECELL 1:5 and Ultraviolet Lamp (UVA);   Device: RECELL 1:10 and Ultraviolet Lamp (UVA);   Device: RECELL 1:20 and Ultraviolet Lamp (UVA) Sponsor:   Avita Medical Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 9 January 2020Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): James Nguyen, Navdeep Singh, Salma Afifi, Sergio Giralt, Mario E. Lacouture, Klaus J. Busam, Hani Hassoun
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
Bone Marrow Transplantation, Published online: 29 July 2019; doi:10.1038/s41409-019-0626-xVitiligo following stem-cell transplant
Source: Bone Marrow Transplantation - Category: Hematology Authors: Source Type: research
CONCLUSION: Our study shows that the NCES technique has a high therapeutic effect, is safe for patients with stable vitiligo, and may be a very promising potential option for treating children. PMID: 31084382 [PubMed - as supplied by publisher]
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
Hui Zhou, Xiaoyan Fu, Qian Li and Ting Niu* Department of Hematology and Research Laboratory of Hematology, West China Hospital, Sichuan University, Chengdu, China Background: Immune checkpoint inhibition therapy with monoclonal antibody against programmed cell death protein 1 (PD-1), including nivolumab and pembrolizumab, has demonstrated powerful clinical efficacy in the treatment of advanced cancers. However, there is no evidence-based systematic review on the safety and efficacy of anti-PD-1 antibody in treating lymphoma. Methods: To evaluate the safety and efficacy of nivolumab/pembrolizumab, we analyzed clin...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Conclusion: Our study provides a promising approach for melanocyte transplantation to treat vitiligo.
Source: Indian Journal of Dermatology, Venereology and Leprology - Category: Dermatology Authors: Source Type: research
Conclusions Epidemiological studies have repeatedly helped identify definitive triggers for several diseases. As highlighted in this perspective report, previous studies strongly argue for the interplay between intrinsic factors and putative preventable extrinsic triggers/promoters for CTCL. Given the evidence of geographical regional clustering of CTCL patients, CTCL occurrence in unrelated family members and recent evidence implicating S. aureus in the pathogenesis/progression of CTCL, more research is needed to decipher the precise mechanism by which specific environmental exposures may be driving the pathogenesis of t...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Qiancheng Deng1, Yangyang Luo1,2, Christopher Chang3, Haijing Wu1, Yan Ding4* and Rong Xiao1* 1Hunan Key Laboratory of Medical Epigenetics, Department of Dermatology, The Second Xiangya Hospital, Central South University, Changsha, China 2Department of Dermatology, Hunan Children's Hospital, Changsha, China 3Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, Davis, CA, United States 4Department of Dermatology, Hainan Provincial Dermatology Disease Hospital, Haikou, China Autoimmune diseases are usually complex and multifactorial, characterized by aberrant produc...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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