PharmaMar and Jazz Pharmaceuticals Announce FDA Acceptance and Priority Review of New Drug Application for Lurbinectedin in Relapsed Small Cell Lung Cancer
Prescription Drug User Fee Act (PDUFA) date set for August 16, 2020. MADRID and DUBLIN, Feb. 17, 2020 -- (Healthcare Sales &Marketing Network) -- PharmaMar (MSE:PHM) and Jazz Pharmaceuticals plc (Nasdaq: JAZZ) announce that the U.S. Food and Drug Admi... Biopharmaceuticals, Oncology, FDA Jazz Pharmaceuticals, PharmaMar , lurbinectedin
Contributor : H F JuanSeries Type : Expression profiling by arrayOrganism : Homo sapiensCitreoviridin can suppress lung cancer cell growth by inhibiting the activity of ectopic ATP synthase, but has limited effect on normal cells. However, the mechanism of citreoviridin triggering dynamic molecular responses in cancer cells remains unclear. Here, we performed gene expression profiling to elucidate the dynamic changes after citreoviridin treatment in cells.
In conclusion, a JEM can be a very handy too l for exposure assessment in occupational epidemiology, particularly in large-scale studies with limited occupational information. When selecting the most suitable exposure assessment method, however, researchers should always remain critical. Know when a JEM has added value and recognize its limita tions. References 1. Hoar SK, Morrison AS, Cole P, Silverman DT. An occupation and exposure linkage system for the study of occupational carcinogenesis. J Occup Med. 1980;22(11):722-6. 2. Pannett B, Coggon D, Acheson ED. A job-exposure matrix for use in population based studies in ...
Publication date: Available online 30 March 2020Source: Journal of EthnopharmacologyAuthor(s): Zu-Jun Que, Bin Luo, Chen-Tong Wang, Fang-Fang Qian, Yi Jiang, Yan Li, Xiang-Hui Han, He-Gen Li, Jia-Xiang Liu, Jian-Hui Tian
This study evaluated the distribution of the crizotinib patient information brochure (PIB) in Europe and patient knowledge of the key messages in the PIB. A cross‐sectional survey was conducted in 10 European countries among pa tients who received crizotinib to ascertain whether each patient received and read the PIB, and his/her knowledge of its key messages on hepatotoxicity, interstitial lung disease/pneumonitis, QTc prolongation, bradycardia, and vision disorders. Of the 341 patients contacted, 40 responded (11.7%), an d 39 patients were eligible. A total of 77% of respondents acknowledged receiving the PIB, of which...
ConclusionThe results of this study showed that there are some differences in term of protein content between the normal and cancerous lung tissues. Further studies are needed to evaluate these proteins that investigate whether these proteins can candidate as biomarkers to use in the early diagnosis of patients with NSCLC.
Publication date: July 2020Source: Materials Science and Engineering: C, Volume 112Author(s): Jun Tang, Fushuang Zheng, Jungang Zhao, Jianzhu Zhao
Researchers determined that artificial intelligence could help predict responses to systemic therapies for patients with non-small cell lung cancer by utilizing CT scans.
AbstractBackgroundSubxiphoid uniportal video ‐assisted thoracoscopic surgery (SVATS) is more technically challenging than intercostal uniportal video‐assisted thoracoscopic surgery (UVATS), especially in more complex procedures such as segmentectomy. We therefore aimed to investigate the worthiness of undertaking the more demanding subxiph oid approach in patients who had undergone anatomical segmentectomy for stage IA non‐small cell lung cancer (NSCLC).MethodsA total of 491 patients were included in our study who had undergone anatomical segmentectomy for stage IA non ‐small cell lung cancer from September 2014 to...