High level of circulating microRNA-142 is associated with acute myocardial infarction and reduced survival
AbstractBackgroundRecent study reported that microRNA-142 (miR-142) were up-regulated in the atherosclerotic plaques, which may be responsible for pathogenesis of atherosclerosis. However, whether it associates with presence of acute myocardial infarction (AMI), and its prognostic value is still unknown. We, therefore, investigated the association between miR-142 expression and presence of AMI, and its prognostic value in AMI patients.MethodsWe included 300 AMI patients and 100 subjects as the control group. MiR-142 content was detected by quantitative real-time polymerase chain reaction. MiR-142 level was identified in all subjects. The multivariate logistic regression analysis were performed to evaluate the risk factors of AMI. The Kaplan –Meier analysis was performed to determine the major adverse cardiovascular and cerebrovascular events (MACCE)-free survival.ResultsAMI group had significantly higher miR-142 level in comparison to the controls [4.10 (2.03 –7.43) vs. 1.92 (0.91–2.91),p
Heart attack symptoms include chest pain, difficulty breathing, and an overwhelming feeling of anxiety. But you could also be at risk of a deadly myocardial infarction and heart disease if you have painful lumps on your feet - do your toes look like this?
ZOLL Medical, now a part of Asahi Kasei Group, won FDA approval for the latest version of its TherOx System. The product is designed to deliver SuperSaturated Oxygen (SSO2) therapy to limit heart muscle loss following “widowmaker” heart a...
A new study assessed the prognosis of myocardial infarction with non-obstructive coronary arteries as compared with myocardial infarction with obstructive coronary artery disease.European Heart Journal
Right ventricular dysfunction impacts the prognosis of various heart diseases. We set-out to examine which right ventricular functional parameters after STEMI and NSTEMI have prognostic value. Of 297 eligible ...
Increased mean platelet volume (MPV) has been associated with elevated risk of stroke and myocardial infarction in the general population and stroke/pump thrombosis in Heartmate II recipients. It has been proposed that contact with foreign surfaces and centrifugation promote prothrombotic states with platelet activation and increased MPV. An association between MPV and outcomes of patients treated with percutaneous short-term circulatory devices has not been investigated.
Acute coronary syndromes (ACS) are one of the most frequent conditions for admission to cardiology worldwide. Ethnic differences in the prevalence of cardiovascular risk factors,1,2 coronary atherosclerosis patterns,3-5 ischemic heart disease presentation,6,7 response to cardiovascular medications,8 and outcomes after myocardial infarction and revascularization9,10 have been reported between two of the world's largest ethnic groups: Asians and Whites. Little is known about the differences in the pathobiology of ACS between these two ethnic groups.
Anemia may confer a poor prognosis among patients with acute coronary syndrome. However, contemporary data are lacking on the prognostic importance of anemia in patients with left ventricular (LV) systolic dysfunction after acute myocardial infarction (AMI).
Incomplete restoration of myocardial blood flow (MBF) is reported in up to 30% of ST-segment elevation myocardial infarction (STEMI) despite prompt mechanical revascularization. Experimental hyperinsulinemic euglycemia (HE) increases MBF reserve (MBFR). If fully exploited, this effect may also improve MBF to ischemic myocardium. Using insulin-dextrose infusions to induce HE, we conducted four experiments to determine (1) how insulin infusion duration, dose, and presence of insulin resistance affect MBFR response; and (2) the effect of an insulin-dextrose infusion given immediately following revascularization of STEMI on myocardial perfusion.
In-hospital mortality of patients with cardiogenic shock complicating ST-elevation myocardial infarction (STEMI-CS) ranges from 30% to 50%. The impact of nosocomial infection(NI) is not well addressed in these patients.
AbstractMechanical complications (MCs) following acute myocardial infarction (AMI), such as ventricular septal rupture (VSR), free-wall rupture (FWR), and papillary muscle rupture (PMR), are fatal. However, the risk factors of in-hospital mortality among patients with MCs have not been previously reported in Japan. The purpose of this study was to evaluate the prognostic factors of in-hospital mortality in these patients. The study cohort consisted of 233 consecutive patients with MCs from the registry of 10 facilities in the Cardiovascular Research Consortium-8 Universities (CIRC-8U) in East Japan between 1997 and 2014 (2...