Outcome in German and South African peripartum cardiomyopathy cohorts associates with medical therapy and fibrosis markers

This study aims to compare the clinical course of peripartum cardiomyopathy (PPCM) cohorts from Germany (G ‐PPCM) and South Africa (SA‐PPCM) with fibrosis‐related markers to get insights into novel pathomechanisms of PPCM.Methods and resultsG ‐PPCM (n = 79) and SA ‐PPCM (n = 72) patients and healthy pregnancy ‐matched women from Germany (n = 56) and South Africa (n = 40) were enrolled. Circulating levels of procollagen type ‐I (PINP) and type‐III (PIIINP) N‐terminal propeptides, soluble ST2, galectin‐3, and full‐length and cleaved osteopontin (OPN) were measured at diagnosis (baseline) and 6 months of follow‐up. Both cohorts received standard heart failure therapy while anticoagulation therapy was applied i n 100% of G‐PPCM but only in 7% of SA‐PPCM patients. In G‐PPCM patients, baseline left ventricular ejection fraction (LVEF) was lower, and outcome was better (baseline LVEF, 24 ± 8%, full recovery: 52%, mortality: 0%) compared with SA‐PPCM patients (baseline LVEF: 30 ± 9%, full recovery: 3 2%, mortality: 11%;P
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Original Research Article Source Type: research

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AbstractMany crucial cardiovascular adaptations occur in the body during pregnancy to ensure successful gestation. Maladaptation of the cardiovascular system during pregnancy can lead to complications that promote cardiac dysfunction and may lead to heart failure (HF). About 12% of pregnancy-related deaths in the USA have been attributed to HF and the detrimental effects of cardiovascular complications on the heart can be long-lasting, pre-disposing the mother to HF later in life. Indeed, cardiovascular complications such as gestational diabetes mellitus, preeclampsia, gestational hypertension, and peripartum cardiomyopath...
Source: Biology of Sex Differences - Category: Biology Source Type: research
This article will provide a comprehensive review and update on this important disease state.
Source: Cardiology in Review - Category: Cardiology Tags: Review Articles Source Type: research
Abstract Peripartum cardiomyopathy (PPCM) is an idiopathic cardiomyopathy that is caused by heart failure secondary to a dysfunction of the left ventricle at the end of pregnancy or in the first months following childbirth. The diagnosis is performed by electrocardiogram, radiography of the thorax and increase of natriuretic peptides. Bedside radiography can contribute with data that help early diagnosis. Treatment is carried out following clinical guidelines for heart failure, taking into account potentially teratogenic drugs. The importance of this pathology lies in that it affects women at a fertile age and is ...
Source: Anales del Sistema Sanitario de Navarra - Category: General Medicine Authors: Tags: An Sist Sanit Navar Source Type: research
Authors: Hänselmann A, Veltmann C, Bauersachs J, Berliner D Abstract Dilated cardiomyopathy (DCM) is the most common form of cardiomyopathy and one of the most common causes of heart failure. It is characterized by left or biventricular dilation and a reduced systolic function. The causes are manifold and range from myocarditis to alcohol and other toxins, to rheumatological, endocrinological, and metabolic diseases. Peripartum cardiomyopathy is a special form that occurs at the end of or shortly after pregnancy. Genetic mutations can be detected in approximately 30-50% of DCM patients. Owing to the ...
Source: Herz - Category: Cardiology Tags: Herz Source Type: research
g;berg M Abstract BACKGROUND: Incidence rates of cardiomyopathies, which are a common cause of heart failure in young people, have increased during the last decades. An association between body weight in adolescence and future cardiomyopathy among men was recently identified. Whether or not this holds true also for women is unknown. The aim was therefore to determine whether for young women being overweight or obese is associated with a higher risk of developing cardiomyopathy. METHODS: This was a registry-based national prospective cohort study with data collected from the Swedish Medical Birth Register, 198...
Source: Circulation - Category: Cardiology Authors: Tags: Circulation Source Type: research
Peripartum cardiomyopathy (PPCM) or pregnancy-associated cardiomyopathy (PAC) occurs all over the world and is one of the leading causes of maternal mortality [1,2]. It is very important to take note of the article in this issue of IJC [3] because it demonstrates the importance of peripartum cardiomyopathy (PPCM) as overwhelmingly the most common cause of pregnancy-associated heart failure. This carefully documented report shows that over a 12-year time period (2003 –2014), 333/488 (68.2%) of those subjects from Southern California, USA, developed pregnancy-associated heart failure because of PPCM.
Source: International Journal of Cardiology - Category: Cardiology Authors: Tags: Editorial Source Type: research
ConclusionsWe report the first data about procreation procedures in France, and wishes of patients, in non-syndromic hereditary heart diseases. This may help to better manage these complex issues in clinical practice.
Source: Archives of Cardiovascular Diseases Supplements - Category: Cardiology Source Type: research
German cancer registry (Robert-Koch-Institute) data has shown a 16 fold risk of cancer in those with peripartum cardiomyopathy [1]. According to the report 21 of 236 patients had cancer, of which 12 had cancer diagnosed before peripartum cardiomyopathy. 11 of them had cardiotoxic chemotherapy. Of these, 17% fully recovered cardiac function compared to 55% of peripartum cardiomyopathy patients without cancer. Of the 10 patients who developed cancer after peripartum cardiomyopathy, 80% had left ventricular ejection fraction of 50% or more after cancer therapy. Authors mention that the high prevalence could be due to geneti...
Source: Cardiophile MD - Category: Cardiology Authors: Tags: Cardio Oncology Source Type: blogs
Ninefold higher cancer occurrence seen both before and after peripartum cardiomyopathy diagnosis
Source: The Doctors Lounge - Oncology - Category: Cancer & Oncology Tags: Cardiology, Family Medicine, Gynecology, Oncology, Pathology, Journal, Source Type: news
WEDNESDAY, Dec. 18, 2019 -- Patients with peripartum cardiomyopathy (PPCM) are more likely to have cancer before PPCM diagnosis and more likely to develop cancer after PPCM, according to a study published in the December issue of the JACC:...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
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